7-Didemethyl Minocycline

Base Information

• Chemical Name: 7-Didemethyl Minocycline
• CAS No.: 5679-00-5
• Molecular Formula: C21H23N3O7
• Molecular Weight: 429.43
• Mol file: 5679-00-5.mol

Synonyms:[4S-(4a,4aa,5aa,12aa)]-7-Amino-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide;7-Amino-6-demethyl-6-deoxytetracycline;7-Aminosancycline;7-Didemethyl Minocycline;(4S,4aS,5aR,12aS)-7-Amino-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide;7-Amino-6-deoxy-6-demethyltetracycline;7-Aminominocycline;7-Didemethyl Minocycline Discontinued See: D439651

Chemical Property of 7-Didemethyl Minocycline

Chemical Property:

• Melting Point: >213?C (dec.)
• Boiling Point: 817.4±65.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• PSA: 187.41000
• Density: 1.65±0.1 g/cm3(Predicted)
• LogP: 0.98430
• Storage Temp.: -20°C Freezer

Purity/Quality:

99%, ^*data from raw suppliers

7-DIDEMETHYL MINOCYCLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Didemethyl Minocycline

There total 7 articles about 7-Didemethyl Minocycline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.1%

7-amino-6-demethyltetracycline → 7-amino-6-desmethyl-6-deoxytetracycline (5679-00-5)

Guidance literature:

With sulfuric acid; 5% rhodium-on-charcoal; hydrogen; In methanol; at 40 ℃; for 8h; under 18751.9 Torr; Temperature; Pressure; Autoclave;

Reference yield: 75.7%

dibenzyl azodicarboxylate (2449-05-0) + sancycline (808-26-4,2696-12-0,15964-02-0,39105-46-9) → 7-amino-6-desmethyl-6-deoxytetracycline (5679-00-5)

Guidance literature:

sancycline; With trifluorormethanesulfonic acid; In tetrahydrofuran; at 0 ℃; for 0.333333h; Inert atmosphere;

dibenzyl azodicarboxylate; In tetrahydrofuran; at 0 ℃; for 5h;

Reference yield:

sancycline (808-26-4,2696-12-0,15964-02-0,39105-46-9) → 7-amino-6-desmethyl-6-deoxytetracycline (5679-00-5)

Guidance literature:

sancycline; With dibenzyl azodicarboxylate; trifluoroacetic acid; at 5 - 10 ℃; for 7h;

With hydrogen; 5%-palladium/activated carbon; In methanol; for 3h; under 2068.65 Torr;

upstream raw materials:

[4S-(4a,12aα)]-7-nitro-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a octahydro-naphthacene-2-carboxylic acid amide

sancycline

dibenzyl azodicarboxylate

demeclocycline hydrochloride

Downstream raw materials:

minocycline Hydrochloride

sancycline

Refernces

• 1、 -. "Synthesis method of minocycline hydrochloride". Paragraph 0319; 0323-0325. . Retrieved 2021/06/21.
• 2、 -. "Substituted Tetracycline Compounds". Page/Page column 114. . Retrieved 2010/12/29.