3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester

Base Information Edit

Chemical Name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester
CAS No.:632-93-9
Molecular Formula:C14H21 N O4
Molecular Weight:267.325
Hs Code.:2933399090
European Community (EC) Number:211-188-0
NSC Number:49528,8910
DSSTox Substance ID:DTXSID6060898
Nikkaji Number:J134.803E
Wikidata:Q27157006
ChEMBL ID:CHEMBL3409638,CHEMBL3189958
Mol file:632-93-9.mol

Synonyms:3,5-Dicarbethoxy-1,4-Dihydrocollidine;3,5-Diethoxycarbonyl-1,4-Dihydro-2,4,6-Trimethylpyridine;Dicarbethoxydihydrocollidine;Diethoxycarbonyldihydrocollidine

Suppliers and Price of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,5-Dicarbethoxy-1,4-dihydro-2,4,6-trimethylpyridine
10g
$ 90.00

TCI Chemical
3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >98.0%(GC)
25g
$ 76.00

TCI Chemical
3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >98.0%(GC)
1g
$ 13.00

TCI Chemical
3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >98.0%(GC)
5g
$ 26.00

Sigma-Aldrich
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 99%
25g
$ 115.00

Chemenu
Diethyl2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate 95%
500g
$ 569.00

Cayman Chemical
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate ≥98%
50g
$ 113.00

Cayman Chemical
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate ≥98%
10g
$ 25.00

Cayman Chemical
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate ≥98%
25g
$ 59.00

Biosynth Carbosynth
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate
25 g
$ 65.00

Total 29 raw suppliers

Chemical Property of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester Edit

Chemical Property:

Appearance/Colour:almost white crystalline powder
Vapor Pressure:0.000123mmHg at 25°C
Melting Point:130-132 °C(lit.)
Refractive Index:1.5280 (estimate)
Boiling Point:335ºC at 760 mmHg
PKA:3.53±0.70(Predicted)
Flash Point:123.3ºC
PSA：64.63000
Density:1.12g/cm3
LogP:2.22870
Storage Temp.:Flammables area
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:267.14705815
Heavy Atom Count:19
Complexity:408

Purity/Quality:

98% ^*data from raw suppliers

3,5-Dicarbethoxy-1,4-dihydro-2,4,6-trimethylpyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=C(C1C)C(=O)OCC)C)C
Description Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.
Uses Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate was used to induce Mallory-Denk body formation in mice in vivo.

Technology Process of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester

There total 27 articles about 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 141-97-9
ethyl acetoacetate

: 75-07-0,9002-91-9
acetaldehyde

: 632-93-9
diethyl 1,4-dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylate

Guidance literature:: With ammonium acetate; sodium dodecyl-sulfate; toluene-4-sulfonic acid; for 1h; ultrasonic irradiation;
DOI:10.1055/s-2008-1042908