Technology Process of Cyclopropanecarboxylic acid,
1-[[(2S)-2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-8-nonen
-1-yl]amino]-2-[4-[[3-(4-pyridinyl)-1-isoquinolinyl]oxy]phenyl]acetyl]amino
]-2-ethenyl-, ethyl ester, (1R,2S)-
There total 6 articles about Cyclopropanecarboxylic acid,
1-[[(2S)-2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-8-nonen
-1-yl]amino]-2-[4-[[3-(4-pyridinyl)-1-isoquinolinyl]oxy]phenyl]acetyl]amino
]-2-ethenyl-, ethyl ester, (1R,2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C35H36N4O6;
With
hydrogenchloride;
In
ethyl acetate;
at 20 ℃;
(S)-2-(tert-butoxycarbonylamino)non-8-enoic acid;
With
4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 20 ℃;
Further stages.;
DOI:10.1016/j.bmc.2006.11.003
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 31 percent / [(t-Bu)3PH]BF4; KF / Pd2(dba)3 / tetrahydrofuran / 0.25 h / 170 °C / microwave irradiation
2.1: HATU; ethyldiisopropylamine / dimethylformamide / 20 °C
3.1: hydrochloric acid / ethyl acetate / 20 °C
3.2: 56 percent / HATU; NMM / dimethylformamide / 20 °C
With
hydrogenchloride; potassium fluoride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tri tert-butylphosphoniumtetrafluoroborate;
tris(dibenzylideneacetone)dipalladium (0);
In
tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
1.1: Suzuki reaction;
DOI:10.1016/j.bmc.2006.11.003
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 99 percent / potassium tert-butoxide / dimethylsulfoxide / 336 h / 40 °C
2.1: 31 percent / [(t-Bu)3PH]BF4; KF / Pd2(dba)3 / tetrahydrofuran / 0.25 h / 170 °C / microwave irradiation
3.1: HATU; ethyldiisopropylamine / dimethylformamide / 20 °C
4.1: hydrochloric acid / ethyl acetate / 20 °C
4.2: 56 percent / HATU; NMM / dimethylformamide / 20 °C
With
hydrogenchloride; potassium fluoride; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tri tert-butylphosphoniumtetrafluoroborate;
tris(dibenzylideneacetone)dipalladium (0);
In
tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
2.1: Suzuki reaction;
DOI:10.1016/j.bmc.2006.11.003
