300831-21-4Relevant articles and documents
Synthetic method of optical activity N-tert-butoxycarbonyl-2-amino-8-nonenoic dicyclohexylamine salt
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, (2018/11/04)
The invention provides a method for preparing optical activity N-tert-butoxycarbonyl-2-amino-8-nonenoic dicyclohexylamine salt, wherein X is halogen. The method realizes configuration inversion through a Mitsunobu reaction, and can obtain an optical purit
HEPATITIS C INHIBITOR COMPOUNDS
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Page/Page column 42, (2011/06/23)
Compounds of the invention, which are macrocyclic peptide analogs containing an acylsulfonamide moiety, maintain good activity against NS3 proteases containing clinically relevant resistance mutations for this class as represented by genotype 1 a R155K, genotype 1 b D168V and genotype 1 a D168V resistance mutations. The compounds of the invention are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.
MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE
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Page/Page column 56, (2009/10/09)
The invention provides compounds inhibitory to the Hepatitis C viral protease, compositions and combinations including the compounds, methods of treatment of conditions wherein inhibition of the Hepatitis C viral protease is medically indicated, and metho