3-chloro-1-(4-octylphenyl)-preopanone

Base Information

• Chemical Name: 3-chloro-1-(4-octylphenyl)-preopanone
• CAS No.: 928165-59-7
• Molecular Formula: C17H25ClO
• Molecular Weight: 280.838
• Hs Code.: 2914700090
• Mol file: 928165-59-7.mol

Synonyms:X6212;

Chemical Property of 3-chloro-1-(4-octylphenyl)-preopanone

Chemical Property:

• Melting Point: 51-52℃
• PSA: 17.07000
• Density: 1.000
• LogP: 5.40120
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-1-(4-octylphenyl)propan-1-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-chloro-1-(4-octylphenyl)-preopanone

There total 3 articles about 3-chloro-1-(4-octylphenyl)-preopanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Octylbenzene (2189-60-8) + 2-chloropropionyl chloride (625-36-5) → 3-chloro-1-(4-octylphenyl)propan-1-one (928165-59-7)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at -10 - -5 ℃; for 3 - 5h; Large scale;

DOI:10.1080/00397911.2018.1536788

Reference yield:

n-octanophenone (1674-37-9) + 2-chloropropionyl chloride (625-36-5) → 3-chloro-1-(4-octylphenyl)propan-1-one (928165-59-7)

Guidance literature:

n-octanophenone; With triethylsilane; titanium tetrachloride; In dichloromethane; at 0 - 30 ℃; for 1.5h;

2-chloropropionyl chloride; With aluminum (III) chloride; In dichloromethane; at 0 - 30 ℃; for 1h; Temperature;

Reference yield:

n-octanophenone (1674-37-9) → 3-chloro-1-(4-octylphenyl)propan-1-one (928165-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1: titanium tetrachloride; triethylsilane / dichloromethane / 3 - 5 h / 0 - 5 °C / Large scale

2: aluminum (III) chloride / dichloromethane / 3 - 5 h / -10 - -5 °C / Large scale

With triethylsilane; aluminum (III) chloride; titanium tetrachloride; In dichloromethane; 2: |Friedel-Crafts Acylation;

DOI:10.1080/00397911.2018.1536788

upstream raw materials:

n-octanophenone

2-chloropropionyl chloride

Octylbenzene

Downstream raw materials:

3-nitro-1-(4-octylphenyl)propan-1-one

1-(3-nitropropyl)-4-octylbenzene

2-nitro-2-[2-(4-octyl-phenyl)ethyl]propane-1,3-diol

fingolimod