625-36-5Relevant articles and documents
SYNTHESIS OF 7,7-DIMETHYLBICYCLO-OCTANE BY ACETYLATING A DICOBALTOHEXACARBONYL 4-METHYLPENT-3-EN-1-YNE-1 COMPLEX
Veretenov, A. L.,Gybin, A. S.,Smit, V. A.,Chertkov, V. A.,Shashkov, A. S.
, p. 1725 - 1733 (1989)
Dicobaltohexacarbonyl 4-methyl-pent-3-en-1-yne complexes have been acylated with acryloyl and crotonoyl tetrafluoroborates followed by methanolysis to make acylmethoxy adducts containing hem-dimethyl moieties.Conditions have been defined under which such adducts containing enone systems are selectively reduced to allyl alcohols with retention of the cobaltocarbonyl moieties.The latter can be converted by Quand-Poson reaction to the inaccessible polyfunctional derivatives of 7,7-dimethylbicyclooctane.
Method for producing high-purity 3-chloropropionyl chloride by one-pot method
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Paragraph 0024-0031, (2021/08/07)
The invention discloses a method for producing high-purity 3-chloropropionyl chloride through a one-pot method, and belongs to the field of fine chemical engineering. Acrylic acid, hydrochloric acid and thionyl chloride are used as raw materials, in the presence of a phenothiazine catalyst, addition reaction, dehydration and acylating chlorination reaction are performed, and simple distillation is performed to obtain 3-chloropropionyl chloride. In the addition stage, the residual acrylic acid in the reaction liquid is strictly controlled to be less than or equal to 2.0% and the moisture is less than or equal to 1.0%; in the acylating chlorination stage, the content of 3-chloropropionyl chloride is strictly controlled to be greater than or equal to 99.0%, the purity of 3-chloropropionyl chloride obtained by distilling the reaction liquid is greater than or equal to 99.5%, and the yield is 90% or above. The 3-chloropropionyl chloride product obtained by the process can meet the requirements of the market on high-purity 3-chloropropionyl chloride.
Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors
Xie, Yiyue,Tummala, Padmaja,Oakley, Aaron J.,Deora, Girdhar Singh,Nakano, Yuji,Rooke, Melissa,Cuellar, Matthew E.,Strasser, Jessica M.,Dahlin, Jayme L.,Walters, Michael A.,Casarotto, Marco G.,Board, Philip G.,Baell, Jonathan B.
, p. 2894 - 2914 (2020/04/08)
Glutathione transferase omega-1 (GSTO1-1) is an enzyme whose function supports the activation of interleukin (IL)-1β and IL-18 that are implicated in a variety of inflammatory disease states for which small-molecule inhibitors are sought. The potent reactivity of the active-site cysteine has resulted in reported inhibitors that act by covalent labeling. In this study, structure-activity relationship (SAR) elaboration of the reported GSTO1-1 inhibitor C1-27 was undertaken. Compounds were evaluated for inhibitory activity toward purified recombinant GSTO1-1 and for indicators of target engagement in cell-based assays. As covalent inhibitors, the kinact/KI values of selected compounds were determined, as well as in vivo pharmacokinetics analysis. Cocrystal structures of key novel compounds in complex with GSTO1-1 were also solved. This study represents the first application of a biochemical assay for GSTO1-1 to determine kinact/KI values for tested inhibitors and the most extensive set of cell-based data for a GSTO1-1 inhibitor SAR series reported to date. Our research culminated in the discovery of 25, which we propose as the preferred biochemical tool to interrogate cellular responses to GSTO1-1 inhibition.