Benzoic acid, 4-[(4-methyl-1-piperazinyl)methyl]-, 2-(5-bromo-2-cyano-4-pyrimidinyl)-2-(2-methylpropyl)hydrazide 2,2,2-trifluoroacetate (1:1)

Base Information

Chemical Name:Benzoic acid, 4-[(4-methyl-1-piperazinyl)methyl]-, 2-(5-bromo-2-cyano-4-pyrimidinyl)-2-(2-methylpropyl)hydrazide 2,2,2-trifluoroacetate (1:1)
CAS No.:928165-90-6
Molecular Formula:C₂HF₃O₂*C₂₂H₂₈BrN₇O
Molecular Weight:600.439
Hs Code.:

Benzoic acid, 4-[(4-methyl-1-piperazinyl)methyl]-,
2-(5-bromo-2-cyano-4-pyrimidinyl)-2-(2-methylpropyl)hydrazide
2,2,2-trifluoroacetate (1:1)

Synonyms:

Suppliers and Price of Benzoic acid, 4-[(4-methyl-1-piperazinyl)methyl]-, 2-(5-bromo-2-cyano-4-pyrimidinyl)-2-(2-methylpropyl)hydrazide 2,2,2-trifluoroacetate (1:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzoic acid, 4-[(4-methyl-1-piperazinyl)methyl]-, 2-(5-bromo-2-cyano-4-pyrimidinyl)-2-(2-methylpropyl)hydrazide 2,2,2-trifluoroacetate (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-[(4-methyl-1-piperazinyl)methyl]-, 2-(5-bromo-2-cyano-4-pyrimidinyl)-2-(2-methylpropyl)hydrazide 2,2,2-trifluoroacetate (1:1)

There total 8 articles about Benzoic acid, 4-[(4-methyl-1-piperazinyl)methyl]-, 2-(5-bromo-2-cyano-4-pyrimidinyl)-2-(2-methylpropyl)hydrazide 2,2,2-trifluoroacetate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 928165-07-5
N'-(5-bromo-2-cyano-4-pyrimidinyl)-4-[(4-methyl-1-piperazinyl) methyl]-N'-(2-methylpropyl)benzohydrazide

: 76-05-1
trifluoroacetic acid

: 928165-90-6
N'-(5-bromo-2-cyano-4-pyrimidinyl)-4-[(4-methyl-1-piperazinyl) methyl]-N'-(2-methylpropyl)benzohydrazide trifluoroacetate

Guidance literature:: In water; acetonitrile;

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 928165-90-6
N'-(5-bromo-2-cyano-4-pyrimidinyl)-4-[(4-methyl-1-piperazinyl) methyl]-N'-(2-methylpropyl)benzohydrazide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 17 h / 20 °C

2.1: lithium hydroxide; water / methanol / 2 h / Heating / reflux

2.2: pH 5

3.1: thionyl chloride / 6 h / Heating / reflux

4.1: pyridine; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

5.1: water; acetonitrile

With pyridine; lithium hydroxide; thionyl chloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 928165-90-6
N'-(5-bromo-2-cyano-4-pyrimidinyl)-4-[(4-methyl-1-piperazinyl) methyl]-N'-(2-methylpropyl)benzohydrazide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 17 h / 20 °C

2.1: lithium hydroxide; water / methanol / 2 h / Heating / reflux

2.2: pH 5

3.1: thionyl chloride / 6 h / Heating / reflux

4.1: pyridine; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

5.1: water; acetonitrile

With pyridine; lithium hydroxide; thionyl chloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;