2-methoxy-6-(methoxymethyl)cyclohexa-2,5-diene-1,4-dione

Base Information

• Chemical Name: 2-methoxy-6-(methoxymethyl)cyclohexa-2,5-diene-1,4-dione
• CAS No.: 104199-06-6
• Molecular Formula: C9H10 O4
• Molecular Weight: 182.1733
• Mol file: 104199-06-6.mol

Synonyms:2,5-Cyclohexadiene-1,4-dione,2-(methoxymethyl)-6-methoxy- (9CI)

Chemical Property of 2-methoxy-6-(methoxymethyl)cyclohexa-2,5-diene-1,4-dione

Chemical Property:

• Vapor Pressure: 0.00329mmHg at 25°C
• Boiling Point: 282.8°Cat760mmHg
• Flash Point: 122.7°C
• Density: 1.19g/cm³

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methoxy-6-(methoxymethyl)cyclohexa-2,5-diene-1,4-dione

There total 2 articles about 2-methoxy-6-(methoxymethyl)cyclohexa-2,5-diene-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-methoxy-6-(methoxymethyl)phenol (104199-12-4) → 2-Methoxy-6-methoxymethyl-[1,4]benzoquinone (104199-06-6)

Guidance literature:

With salcomine; oxygen; In N,N-dimethyl-formamide; for 72h;

DOI:10.1021/jo00373a004

Reference yield:

2-hydroxy-3-methoxybenzyl alcohol (4383-05-5) → 2-Methoxy-6-methoxymethyl-[1,4]benzoquinone (104199-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF

2: 74 percent / oxygen, salcomine / dimethylformamide / 72 h

With salcomine; oxygen; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo00373a004

Reference yield: 97.0%

(E)-3,5-hexadienoic acid (32775-95-4) + 2-Methoxy-6-methoxymethyl-[1,4]benzoquinone (104199-06-6) → ((1R,4aS,8aR)-7-Methoxy-8a-methoxymethyl-5,8-dioxo-1,4,4a,5,8,8a-hexahydro-naphthalen-1-yl)-acetic acid (104199-09-9)

Guidance literature:

In dichloromethane;

DOI:10.1021/jo00373a004

upstream raw materials:

2-methoxy-6-(methoxymethyl)phenol

2-hydroxy-3-methoxybenzyl alcohol

Downstream raw materials:

((1R,4aS,8aR)-7-Methoxy-8a-methoxymethyl-5,8-dioxo-1,4,4a,5,8,8a-hexahydro-naphthalen-1-yl)-acetic acid

((1S,4aS,8aS)-7-Methoxy-8a-methoxymethyl-2-methyl-5,8-dioxo-1,4,4a,5,8,8a-hexahydro-naphthalen-1-yl)-acetic acid

((1S,4aR,8aS)-7-Methoxy-8a-methoxymethyl-2-methyl-5,8-dioxo-1,4,4a,5,8,8a-hexahydro-naphthalen-1-yl)-acetic acid

((1R,4aR,8aR)-7-Methoxy-8a-methoxymethyl-5,8-dioxo-1,4,4a,5,8,8a-hexahydro-naphthalen-1-yl)-acetic acid