4-benzylactone

Base Information

• Chemical Name: 4-benzylactone
• CAS No.: 27675-77-0
• Molecular Formula: C₂₀H₁₈O₇
• Molecular Weight: 370.359
• Mol file: 27675-77-0.mol

Synonyms:2(3H)-Furanone,dihydro-4-(a-hydroxypiperonyl)-3-piperonyl-,(-)- (8CI); (-)-Parabenzlactone; Parabenzlactone

Chemical Property of 4-benzylactone

Chemical Property:

• Vapor Pressure: 4.25E-15mmHg at 25°C
• Boiling Point: 597°Cat760mmHg
• Flash Point: 217.4°C
• PSA: 83.45000
• Density: 1.461g/cm³
• LogP: 2.20930

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzylactone

There total 27 articles about 4-benzylactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(3,4-methylenedioxy)phenylmagnesium bromide (17680-04-5) + trans-3-[(1,3-benzodioxol-5-yl)methyl]-4-formyldihydro-2(3H)-furanone → trans-4-[(1,3-benzodioxol-5-yl)hydroxymethyl]-3-[(1,3-mbenzodioxol-5-yl)methyl]dihydro-2(3H)-furanone (27675-77-0,62210-55-3,139343-40-1)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 1.5h;

DOI:10.1021/jo000472w

Reference yield:

2,3-trans-(α-benzyloxy-3,4-methylenedioxybenzyl)-2-(3,4-methylenedioxybenzyl)butan-4-olide (139219-22-0,139343-48-9) → (3R,4R)-4-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-3-benzo[1,3]dioxol-5-ylmethyl-dihydro-furan-2-one (27675-77-0,62210-55-3,139343-40-1) + (3R,4R)-4-((S)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-3-benzo[1,3]dioxol-5-ylmethyl-dihydro-furan-2-one (27675-77-0,62210-55-3,139343-40-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 2250.2 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

Reference yield:

2,3-trans-(α-benzyloxy-3,4-methylenedioxybenzyl)-2-(3,4-methylenedioxybenzyl)butan-4-olide (139219-22-0,139343-48-9) → (3R,4R)-4-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-3-benzo[1,3]dioxol-5-ylmethyl-dihydro-furan-2-one (27675-77-0,62210-55-3,139343-40-1) + (3R,4R)-4-((S)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-3-benzo[1,3]dioxol-5-ylmethyl-dihydro-furan-2-one (27675-77-0,62210-55-3,139343-40-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 2250.2 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

upstream raw materials:

(3,4-methylenedioxy)phenylmagnesium bromide

(E)-3-(1,3-benzodioxol-5-yl)acryloyl chloride

2-propenyl (Z,E)-3-(1,3-benzodioxol-5-yl)-N-methoxy-2-propenimidate

(E)-3-(1,3-benzodioxol-5-yl)-N-methoxy-2-propenamide