Chemical Property of Cyclogalegenin
Chemical Property:
- Appearance/Colour:Colorless needle crystal
- Vapor Pressure:8.17E-18mmHg at 25°C
- Refractive Index:1.582
- Boiling Point:617.2 °C at 760 mmHg
- PKA:14.57±0.29(Predicted)
- Flash Point:327.1 °C
- PSA：90.15000
- Density:1.2 g/cm3
- LogP:4.43660
- Storage Temp.:Refrigerator
- Solubility.:Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly)
- XLogP3:4.4
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:2
- Exact Mass:490.36582469
- Heavy Atom Count:35
- Complexity:916
- Purity/Quality:
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99% *data from raw suppliers
Cycloastragenol *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1(C(CCC23C1C(CC4C2(C3)CCC5(C4(CC(C5C6(CCC(O6)C(C)(C)O)C)O)C)C)O)O)C
- Isomeric SMILES:C[C@]12CC[C@@]34C[C@@]35CC[C@@H](C([C@@H]5[C@H](C[C@H]4[C@@]1(C[C@@H]([C@@H]2[C@@]6(CC[C@@H](O6)C(C)(C)O)C)O)C)O)(C)C)O
- Recent ClinicalTrials:Telomerase Activator and Retinal Amyloid
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Description
Cycloastragenol (TA-65), a small-triterpenoid purified from the root of an Asian medicinal herb, has currently received particular attention for its potential to regulate transcription of telomerase. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.
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Uses
Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.
