2-Thiophenecarboxylic acid, 5-aMino-3-[(1R)-1-[2-(trifluoroMethyl)phenyl]ethoxy]-, Methyl ester

Base Information

• Chemical Name: 2-Thiophenecarboxylic acid, 5-aMino-3-[(1R)-1-[2-(trifluoroMethyl)phenyl]ethoxy]-, Methyl ester
• CAS No.: 929039-92-9
• Molecular Formula: C15H14F3NO3S
• Molecular Weight: 345.342
• Hs Code.: 2934999090
• Mol file: 929039-92-9.mol

Synonyms:methyl 5-amino-3-((R)-1-(2-trifluoromethyl-phenyl)-ethoxy)-2-thiophenecarboxylate;(R)-methyl-5-amino-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate;methyl 5-amino-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate;

Chemical Property of 2-Thiophenecarboxylic acid, 5-aMino-3-[(1R)-1-[2-(trifluoroMethyl)phenyl]ethoxy]-, Methyl ester

Chemical Property:

• PSA: 89.79000
• LogP: 4.85690
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-Methyl 5-amino-3-(1-(2-(trifluoromethyl)-phenyl)ethoxy)thiophene-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Thiophenecarboxylic acid, 5-aMino-3-[(1R)-1-[2-(trifluoroMethyl)phenyl]ethoxy]-, Methyl ester

There total 3 articles about 2-Thiophenecarboxylic acid, 5-aMino-3-[(1R)-1-[2-(trifluoroMethyl)phenyl]ethoxy]-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 5-nitro-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate (929039-94-1) → methyl 5-amino-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate (929039-92-9)

Guidance literature:

methyl 5-nitro-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate; With iron; acetic acid; at 50 - 60 ℃; for 2.5h;

With sodium hydroxide; sodium hydrogencarbonate; In water;

Reference yield:

(S)-1-(2-trifluoromethylphenyl)ethanol (79756-81-3,127733-44-2,127852-29-3,127852-27-1) → methyl 5-amino-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate (929039-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane / 21.25 h / 0 - 20 °C

2: iron; acetic acid / 2.5 h / 50 - 60 °C

With PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate; iron; acetic acid; In dichloromethane; 1: Mitsunobu reaction;

Reference yield:

methyl 3-hydroxy-5-nitrothiothiophene-2-carboxylate (89380-77-8) → methyl 5-amino-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate (929039-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane / 21.25 h / 0 - 20 °C

2: iron; acetic acid / 2.5 h / 50 - 60 °C

With PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate; iron; acetic acid; In dichloromethane; 1: Mitsunobu reaction;

upstream raw materials:

methyl 5-nitro-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

(S)-1-(2-trifluoromethylphenyl)ethanol

methyl 3-hydroxy-5-nitrothiothiophene-2-carboxylate

Downstream raw materials:

Methyl 5-[(4-bromo-2-nitrophenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]-ethyl}oxy)thiophene-2-carboxylate

methyl 5-[(5-{[(2,2-dimethylpropanoyl)oxy]methyl}-2-nitrophenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

methyl 5-[(5-{[(methyloxy)methyl]oxy}-2-nitrophenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

methyl 5-({5-[bis(methyloxy)methyl]-2-nitrophenyl}amino)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate