2-Thiophenecarboxylic acid, 5-nitro-3-[(1R)-1-[2-(trifluoroMethyl)phenyl]ethoxy]-, Methyl ester

Base Information

• Chemical Name: 2-Thiophenecarboxylic acid, 5-nitro-3-[(1R)-1-[2-(trifluoroMethyl)phenyl]ethoxy]-, Methyl ester
• CAS No.: 929039-94-1
• Molecular Formula: C15H12F3NO5S
• Molecular Weight: 375.325
• Hs Code.: 2934999090
• Mol file: 929039-94-1.mol

Synonyms:methyl 5-nitro-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate;methyl 3-((R)-1-(2-trifluoromethyl-phenyl)-ethoxy)-5-nitro-2-thiophenecarboxylate;(R)-Methyl 5-nitro-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate;2-Thiophenecarboxylic acid,5-nitro-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-,methyl ester;

Chemical Property of 2-Thiophenecarboxylic acid, 5-nitro-3-[(1R)-1-[2-(trifluoroMethyl)phenyl]ethoxy]-, Methyl ester

Chemical Property:

• PSA: 109.59000
• LogP: 5.12490
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-Methyl 5-nitro-3-(1-(2-(trifluoromethyl)-phenyl)ethoxy)thiophene-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenecarboxylic acid, 5-nitro-3-[(1R)-1-[2-(trifluoroMethyl)phenyl]ethoxy]-, Methyl ester

There total 2 articles about 2-Thiophenecarboxylic acid, 5-nitro-3-[(1R)-1-[2-(trifluoroMethyl)phenyl]ethoxy]-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-1-(2-trifluoromethylphenyl)ethanol (79756-81-3,127733-44-2,127852-29-3,127852-27-1) + methyl 3-hydroxy-5-nitrothiothiophene-2-carboxylate (89380-77-8) → methyl 5-nitro-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate (929039-94-1)

Guidance literature:

(S)-1-(2-trifluoromethylphenyl)ethanol; methyl 3-hydroxy-5-nitrothiothiophene-2-carboxylate; With polymer supported triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 0 - 20 ℃; for 21.25h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield: 98.0%

(S)-1-(2-(trifluoromethyl)phenyl)ethanol (79756-81-3,127733-44-2,127852-27-1,127852-29-3) + methyl 3-hydroxy-5-nitrothiothiophene-2-carboxylate (89380-77-8) → methyl 5-nitro-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate (929039-94-1)

Guidance literature:

(S)-1-(2-(trifluoromethyl)phenyl)ethanol; methyl 3-hydroxy-5-nitrothiothiophene-2-carboxylate; With PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate; In dichloromethane; at 20 ℃; for 21.25h;

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2008.08.077

Reference yield: 92.0%

methyl 5-nitro-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate (929039-94-1) → methyl 5-amino-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate (929039-92-9)

Guidance literature:

methyl 5-nitro-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate; With iron; acetic acid; at 50 - 60 ℃; for 2.5h;

With sodium hydroxide; sodium hydrogencarbonate; In water;

upstream raw materials:

(S)-1-(2-trifluoromethylphenyl)ethanol

methyl 3-hydroxy-5-nitrothiothiophene-2-carboxylate

(S)-1-(2-(trifluoromethyl)phenyl)ethanol

Downstream raw materials:

methyl 5-amino-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

methyl 5-[6-(hydroxymethyl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

methyl 5-(6-{[(2,2-dimethylpropanoyl)oxy]methyl}-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

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