Chemical Property of Desmosterol
Chemical Property:
- Appearance/Colour:WHITE POWDER
- Vapor Pressure:2.31E-11mmHg at 25°C
- Melting Point:121.5°, also reported as 119-119.5°
- Refractive Index:1.535
- Boiling Point:483.2 °C at 760 mmHg
- PKA:15.03±0.70(Predicted)
- Flash Point:209.2 °C
- PSA：20.23000
- Density:1 g/cm3
- LogP:7.30880
- Storage Temp.:−20°C
- Solubility.:Chloroform (Slightly), Methanol (Slightly)
- XLogP3:8.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:4
- Exact Mass:384.339216023
- Heavy Atom Count:28
- Complexity:641
- Purity/Quality:
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99% *data from raw suppliers
Desmosterol *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CC(CCC=C(C)C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
- Isomeric SMILES:C[C@H](CCC=C(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
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Uses
24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies. During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols. However, defects in cholesterol synthesis can lead to a condition called, desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol. 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.[Cayman Chemical] Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers. A metabolite of Cholesterol (C432501).
