Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Nle-NH2

Base Information

• Chemical Name: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Nle-NH2
• CAS No.: 57462-42-7
• Molecular Formula: C₆₄H₁₀₀N₁₈O₁₃
• Molecular Weight: 1329.61
• ChEMBL ID: CHEMBL405720
• Mol file: 57462-42-7.mol

Synonyms:11-NleNH2-SP;11-NleNH2-substance P;substance P, NleNH2(11)-;substance P, norleucinamide(11)-

Chemical Property of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Nle-NH2

Chemical Property:

• PSA: 516.63000
• LogP: 4.63120
• Storage Temp.: −20°C
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 15
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 42
• Exact Mass: 1328.77172532
• Heavy Atom Count: 95
• Complexity: 2610

Purity/Quality:

98%Min ^*data from raw suppliers

[Nle11]-SubstanceP ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCC(C(=O)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N
• Isomeric SMILES: CCCC[C@@H](C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCN=C(N)N)N

Technology Process of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Nle-NH2

There total 1 articles about Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Nle-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-glycine (4530-20-5) + N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + Boc-Nle-OH (6404-28-0) → [Nle11 ]-substance P (57462-42-7)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jm00343a012

upstream raw materials:

BOC-glycine

N-tert-butoxycarbonyl-L-leucine

N-tert-butoxycarbonyl-L-phenylalanine

Boc-Nle-OH

Refernces