1,2-di(1H-indol-3-yl)ethane-1,2-dione

Base Information

• Chemical Name: 1,2-di(1H-indol-3-yl)ethane-1,2-dione
• CAS No.: 65610-87-9
• Molecular Formula: C18H12N2O2
• Molecular Weight: 288.305
• Mol file: 65610-87-9.mol

Synonyms:

Chemical Property of 1,2-di(1H-indol-3-yl)ethane-1,2-dione

Chemical Property:

• Vapor Pressure: 6.21E-14mmHg at 25°C
• Boiling Point: 590.8°Cat760mmHg
• Flash Point: 298.7°C
• Density: 1.404g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-di(1H-indol-3-yl)ethane-1,2-dione

There total 10 articles about 1,2-di(1H-indol-3-yl)ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

indole (120-72-9) + indolyl-3-glyoxylyl chloride (22980-09-2) → 1,2-bis(1H-indol-3-yl)ethane-1,2-dione (65610-87-9)

Guidance literature:

aluminium trichloride; In n-heptane; 1,2-dichloro-ethane; at 18 - 20 ℃; for 2h;

DOI:10.1007/s11178-005-0258-z

Reference yield: 71.0%

indole (120-72-9) + 3-indolylglyoxal (7269-72-9) → 1,2-bis(1H-indol-3-yl)ethane-1,2-dione (65610-87-9)

Guidance literature:

With copper(II) acetate monohydrate; acetic acid; In 1,4-dioxane; at 100 ℃; for 7h;

DOI:10.1039/c7ob01255a

Reference yield: 46.0%

indole (120-72-9) + indolyl-3-glyoxylyl chloride (22980-09-2) + ethylmagnesium bromide (925-90-6) → 1,2-bis(1H-indol-3-yl)ethane-1,2-dione (65610-87-9)

Guidance literature:

indole; ethylmagnesium bromide; With zinc(II) chloride; In diethyl ether; at 20 ℃; for 0.5h;

indolyl-3-glyoxylyl chloride; In diethyl ether; at 20 ℃; for 3.5h;

DOI:10.1039/c4nj01728e

upstream raw materials:

indole

indolyl-3-glyoxylyl chloride

oxalyl dichloride

1,2-di(1H-indol-3-yl)ethane

Downstream raw materials:

1H-indole-3-carboxylic acid

Refernces

• 1、 Krayushkin,Yarovenko,Sedishev,Zavarzin,Vorontsova,Starikova. "Synthesis and structure of 5-indolyl-6-thienyl-1,2,4-triazines". . p. 875 - 883. Retrieved 2005.
• 2、 Wang, Cuiping,Zhang, Zhiqiang,Liu, Kui,Yan, Jingbo,Zhang, Tiexin,Lu, Gonghao,Meng, Qingtao,Chi, Haijun,Duan, Chunying. "Copper-catalyzed synthesis of indolyl diketones: Via C-H oxidation/diacylation of indoles with arylglyoxal hydrates". supporting information. p. 6185 - 6193. Retrieved 2017/08/02.
• 3、 Blair, Lachlan M.,Sperry, Jonathan. "Palladium-catalyzed heteroannulation approach to 1,2-bis(3-indolyl)ethanes". . p. 1931 - 1936. Retrieved 2013/09/24.