6H-Purin-6-one, 2-amino-1,9-dihydro-9-phenyl-

Base Information

• Chemical Name: 6H-Purin-6-one, 2-amino-1,9-dihydro-9-phenyl-
• CAS No.: 14443-33-5
• Molecular Formula: C11H9N5O
• Molecular Weight: 227.225
• Hs Code.: 2933990090
• Mol file: 14443-33-5.mol

Synonyms:Guanine,9-phenyl- (6CI,8CI);9-Phenylguanine;NSC 26289;

Chemical Property of 6H-Purin-6-one, 2-amino-1,9-dihydro-9-phenyl-

Chemical Property:

• Vapor Pressure: 1E-10mmHg at 25°C
• Refractive Index: 1.804
• Boiling Point: 515.2 ℃at 760 mmHg
• Flash Point: 265.4 ℃
• PSA: 89.59000
• Density: 1.58 g/cm³
• LogP: 1.27220
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-9-phenyl-1H-purin-6(9H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6H-Purin-6-one, 2-amino-1,9-dihydro-9-phenyl-

There total 10 articles about 6H-Purin-6-one, 2-amino-1,9-dihydro-9-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

di(tert-butyl) 6-chloro-9-phenyl-9H-purin-6-yliminodicarbonate → 2-amino-9-phenyl-1H-purin-6(9H)-one (14443-33-5)

Guidance literature:

With hydrogenchloride; acetic acid; at 90 ℃; for 17h;

DOI:10.1021/jo061694i

Reference yield: 86.0%

2-N-acetyl-6-O-diphenylcarbamoyl-9-N’-phenylguanine (1485770-83-9) → 2-amino-9-phenyl-1H-purin-6(9H)-one (14443-33-5)

Guidance literature:

With ammonia; In methanol; at 70 ℃; Inert atmosphere;

DOI:10.1021/jm401369y

Reference yield: 78.0%

2-amino-1,9-dihydro-6H-purin-6-one (73-40-5) + O-phenyl N,N-diethylcarbamate (65009-00-9) → 2-amino-9-phenyl-1H-purin-6(9H)-one (14443-33-5)

Guidance literature:

With sodium t-butanolate; In ethylene glycol; at 100 ℃; for 12h;

DOI:10.1039/d0nj01610a

upstream raw materials:

N²,N²-bis-boc-2-amino-6-chloropurine

phenylboronic acid

2-N-acetyl-6-O-diphenylcarbamoyl-9-N’-phenylguanine

bromobenzene

Downstream raw materials:

9-phenyl-3,9-dihydro-purine-2,6-dione

Refernces

• 1、 Larsen, Anders Foller,Ulven, Trond. "Direct N9-arylation of purines with aryl halides". supporting information. p. 4997 - 4999. Retrieved 2014/05/06.
• 2、 Jacobsen, Mikkel F.,Knudsen, Martin M.,Gothelf, Kurt V.. "Efficient N-arylation and N-alkenylation of the five DNA/RNA nucleobases". . p. 9183 - 9190. Retrieved 2007/10/03.