Chemical Property of CID 16057735
Chemical Property:
- Appearance/Colour:White or off white crystalline powder
- Vapor Pressure:2.87E-06mmHg at 25°C
- Melting Point:149 ºC
- Refractive Index:1.5200 (estimate)
- Boiling Point:389.4 ºC at 760 mmHg
- PKA:8.39(at 25℃)
- Flash Point:189.3 ºC
- PSA：41.57000
- Density:1.1279 (rough estimate)
- LogP:3.49200
- Storage Temp.:Refrigerator
- Solubility.:alcohol: solublesoluble 40 parts of solvent
- Water Solubility.:Soluble in water at 50mg/ml
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:9
- Exact Mass:300.1604557
- Heavy Atom Count:20
- Complexity:249
- Purity/Quality:
-
99.0%, *data from raw suppliers
Tetracaine Hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25-36-43-42/43
- Safety Statements:
26-36/37-45-36/37/39-22-53
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CCCCNC1=CC=C(C=C1)C(=O)OCC[NH+](C)C.[Cl-]
-
Description
Tetracaine Hydrochloride is a local anesthetic drug composed of amphiphilic molecules of a tertiary amine, exhibiting colloidal properties in aqueous media. [1]
-
Uses
Tetracaine Hydrochloride is a local anesthetic commonly used for pain control during procedures such as skin laceration repair or ophthalmic surgery. Recent evidence suggests its potential antitumor effects in various cancers, including neuroblastoma, breast cancer, and melanoma. [3]
-
Mechanism of Action
Role of Tetracaine Hydrochloride as an Organic Counterion: Tetracaine Hydrochloride serves as an organic counterion, enhancing the micellization properties of ionic surfactants such as sodium bis(2-ethylhexyl) sulfosuccinate (AOT) and sodium dodecyl sulfate (SDS) in aqueous media. [1]
TCH exhibits colloidal properties in aqueous media and undergoes micellization similar to other surface-active molecules. [2]
Tetracaine hydrochloride exerts its effects by downregulating heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), a protein implicated in tumor development and progression. [3]
-
History and Development
Tetracaine Hydrochloride (TCH) is an amphiphilic anesthetic drug with a long-acting ester, synthesized in 1928. TCH is initially formulated as tetracaine hydrochloride, and its aqueous dissolution creates a bioactive species (TCH+), which acts by entering the ionic channel of the cell membrane to stop pain sensation along the nerve. [2]
-
References
[1] Binding behaviour of hydrophobic drug tetracaine hydrochloride used as organic counterion on ionic surfactants (DOI 10.1016/j.molliq.2021.116564)
[2] Investigation of an anaesthetic drug (tetracaine hydrochloride) in the presence of ionic fluid and surfactant: Mixed micellization & spectroscopic studies (DOI 10.1016/j.molliq.2022.121057)
[3] Tetracaine hydrochloride induces cell cycle arrest in melanoma by downregulating hnRNPA1 (DOI 10.1016/j.taap.2021.115810)
