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Joro spider toxin

Base Information Edit
  • Chemical Name:Joro spider toxin
  • CAS No.:112163-33-4
  • Molecular Formula:C27H47N7O6
  • Molecular Weight:565.713
  • Hs Code.:3502200000
  • European Community (EC) Number:690-703-4
  • UNII:MPT5X293RB
  • DSSTox Substance ID:DTXSID50149933
  • Nikkaji Number:J366.795B
  • Wikipedia:Joro_toxin
  • Wikidata:Q12161794
  • Pharos Ligand ID:H2U7TKVBSK5B
  • Metabolomics Workbench ID:68127
  • ChEMBL ID:CHEMBL313747
  • Mol file:112163-33-4.mol
Joro spider toxin

Synonyms:Joro spider toxin;JSTX;JSTX spider toxin

Suppliers and Price of Joro spider toxin
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • JoroSpiderToxin
  • 1mg
  • $ 5445.00
  • TRC
  • JoroSpiderToxin
  • 0.1mg
  • $ 985.00
  • Aaron Chemicals
  • JoroSpiderToxin 95%
  • 5g
  • $ 539.00
  • Aaron Chemicals
  • JoroSpiderToxin 95%
  • 1g
  • $ 182.00
Total 54 raw suppliers
Chemical Property of Joro spider toxin Edit
Chemical Property:
  • Vapor Pressure:0mmHg at 25°C 
  • Refractive Index:1.558 
  • Boiling Point:979.883 °C at 760 mmHg 
  • PKA:9.53±0.35(Predicted) 
  • Flash Point:546.414 °C 
  • PSA:220.93000 
  • Density:1.196 g/cm3 
  • LogP:2.45660 
  • Storage Temp.:−20°C 
  • Solubility.:DMSO (Slightly), Water (Slightly) 
  • XLogP3:-1.8
  • Hydrogen Bond Donor Count:9
  • Hydrogen Bond Acceptor Count:9
  • Rotatable Bond Count:23
  • Exact Mass:565.35878224
  • Heavy Atom Count:40
  • Complexity:742
Purity/Quality:

98%,99%, *data from raw suppliers

JoroSpiderToxin *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 22 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1=CC(=C(C=C1O)O)CC(=O)NC(CC(=O)N)C(=O)NCCCCCNC(=O)CCNCCCCNCCCN
  • Isomeric SMILES:C1=CC(=C(C=C1O)O)CC(=O)N[C@@H](CC(=O)N)C(=O)NCCCCCNC(=O)CCNCCCCNCCCN
  • description Lactoferrin (formerly known as lactotransferrin) is a glycoprotein, and a member of a transferrin family, thus belonging to those proteins capable of binding and transferring Fe3+ ions (Metz-Boutique et al., 1984).It is produced by various mammals and is found in milk, nasal secretions, saliva and tears, and it is in great abundance in human colostrum. It has intrigued scientists for decades.Lactoferrin was first isolated by Sorensen and Sorensen from bovine milk in 1939. In 1960 it was concurrently determined to be the main iron binding protein in human milk by three independent laboratories (Groves, 1960; Johanson, 1960; Montreuil et al., 1960).Subsequent research identified lactoferrin in secretions from exocrine glands and in specific granules of neutrophils. Neutrophils after degranulation were obser ved to be the main source of lactoferrin in blood plasma (Iyer and Lonnerdal, 1993).Due to the increase in its concentration during most inflammatory reactions and some viral in fections, several authors classify lactoferrin as an acute-phase protein (Kanyshkova et al., 2001). Its concentration increases in all biological fluids, but the highest levels have been detected in the nidus of inflammation (Birgens, 1985).Thus, lactoferrin has a wide variety of biological functions, many of which do not appear to be connected with its iron binding ability (Brock, 2002).
  • Uses Lactoferrin is a multifunctional protein of transferin family. A glycoprotein present in various secretions including milk, saliva and tears. Antiviral agent, it binds to liproproteins of cell membranes dispersing virus molecules from host cells. Lactoferrin is used for treating stomach and intestinal ulcers, diarrhea, and hepatitis C. It is also used as an antioxidant and to protect against bacterial and viral infections. Other uses include stimulating the immune system, preventing tissue damage related to aging, promoting healthy intestinal bacteria, preventing cancer, and regulating the way the body processes iron.
Technology Process of Joro spider toxin

There total 12 articles about Joro spider toxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 6 steps
1: dimethylformamide / 0.5 h / 20 °C
2: 92 percent / Cs2CO3 / dimethylformamide / 1 h / 50 °C
3: TFA / CHCl3 / 1 h / 0 - 20 °C
4: Et3N / dimethylformamide / 2 h / 20 °C
5: 2-mercaptoethanol; DBU / dimethylformamide / 0.5 h / 20 °C
6: H2; AcOH / Pd(OH)2 / 3 h / 20 °C
With hydrogen; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; 2-hydroxyethanethiol; palladium dihydroxide; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00733-8
Guidance literature:
Multi-step reaction with 9 steps
1: Et3N / CH2Cl2 / 2 h / 0 - 20 °C
2: 96 percent / aq. NaOH / methanol / 1 h / 0 - 20 °C
3: DCC / CH2Cl2 / 5 h / 0 °C
4: dimethylformamide / 0.5 h / 20 °C
5: 92 percent / Cs2CO3 / dimethylformamide / 1 h / 50 °C
6: TFA / CHCl3 / 1 h / 0 - 20 °C
7: Et3N / dimethylformamide / 2 h / 20 °C
8: 2-mercaptoethanol; DBU / dimethylformamide / 0.5 h / 20 °C
9: H2; AcOH / Pd(OH)2 / 3 h / 20 °C
With sodium hydroxide; hydrogen; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 2-hydroxyethanethiol; palladium dihydroxide; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00733-8
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