2-Oxazolidinone, 3-[(2S,3R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1-oxo-3-[(tri ethylsilyl)oxy]heptyl]-4-(phenylmethyl)-, (4S)-

Base Information

Chemical Name:2-Oxazolidinone, 3-[(2S,3R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1-oxo-3-[(tri ethylsilyl)oxy]heptyl]-4-(phenylmethyl)-, (4S)-
CAS No.:929298-20-4
Molecular Formula:C40H57NO5Si2
Molecular Weight:688.067
Hs Code.:

Synonyms:

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Chemical Property of 2-Oxazolidinone, 3-[(2S,3R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1-oxo-3-[(tri ethylsilyl)oxy]heptyl]-4-(phenylmethyl)-, (4S)-

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Technology Process of 2-Oxazolidinone, 3-[(2S,3R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1-oxo-3-[(tri ethylsilyl)oxy]heptyl]-4-(phenylmethyl)-, (4S)-

There total 5 articles about 2-Oxazolidinone, 3-[(2S,3R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1-oxo-3-[(tri ethylsilyl)oxy]heptyl]-4-(phenylmethyl)-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 4-benzyl-3-[7-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-heptanoyl]-oxazolidin-2-one

: 994-30-9
triethylsilyl chloride

: 929298-20-4
4-benzyl-3-[7-(tert-butyl-diphenyl-silanyloxy)-2-methyl-3-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1135/cccc2008181

Reference yield:

: 111-29-5
1 ,5-pentanediol

: 929298-20-4
4-benzyl-3-[7-(tert-butyl-diphenyl-silanyloxy)-2-methyl-3-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 72 percent / imidazole; DMAP / CH₂Cl₂ / 12 h / 20 °C

2.1: 87 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

3.1: dibutylboron triflate; ethyldiisopropylamine / CH₂Cl₂ / -78 - 0 °C

3.2: 94 percent / CH₂Cl₂ / 4 h / 0 °C

4.1: 15.8 g / imidazole; DMAP / CH₂Cl₂; dimethylformamide / 3 h / 20 °C

With 1H-imidazole; dmap; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 2.1: Swern oxidation;
DOI:10.1021/ol063083i

Reference yield:

: 131216-47-2
5-(tert-butyldiphenylsilyloxy)pentanal

: 929298-20-4
4-benzyl-3-[7-(tert-butyl-diphenyl-silanyloxy)-2-methyl-3-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: dibutylboron triflate; ethyldiisopropylamine / CH₂Cl₂ / -78 - 0 °C

1.2: 94 percent / CH₂Cl₂ / 4 h / 0 °C

2.1: 15.8 g / imidazole; DMAP / CH₂Cl₂; dimethylformamide / 3 h / 20 °C

With 1H-imidazole; dmap; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol063083i