Delorazepam

Base Information

• Chemical Name: Delorazepam
• CAS No.: 2894-67-9
• Molecular Formula: C15H10Cl2N2O
• Molecular Weight: 305.163
• European Community (EC) Number: 220-771-9
• NSC Number: 169895
• UNII: O91W32476G
• DSSTox Substance ID: DTXSID70183137
• Nikkaji Number: J7.928F
• Wikipedia: Delorazepam
• Wikidata: Q3705147
• NCI Thesaurus Code: C98132
• Metabolomics Workbench ID: 146161
• ChEMBL ID: CHEMBL268254
• Mol file: 2894-67-9.mol

Synonyms:2'-chloronordiazepam;7-chloro-5-(2-chlorophenyl) 1,3-dihydro-2H-1,4-benzodiazepin-2-one;chlordemethyldiazepam;chlordesmethyldiazepam;chlorodesmethyldiazepam;delorazepam

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Delorazepam

Chemical Property:

• Appearance/Colour: Off-white to light yellow solid
• Vapor Pressure: 1.94E-09mmHg at 25°C
• Melting Point: 187-189 °C
• Refractive Index: 1.673
• Boiling Point: 481.7 °C at 760 mmHg
• PKA: 11.58±0.70(Predicted)
• Flash Point: 245.1 °C
• PSA: 41.46000
• Density: 1.42 g/cm³
• LogP: 3.35650
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 304.0170183
• Heavy Atom Count: 20
• Complexity: 413

Purity/Quality:

Safty Information:

• Pictogram(s): Xn, T, F
• Hazard Codes: Xn,T,F
• Statements: 22-39/23/24/25-23/24/25-11
• Safety Statements: 36/37/39-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3Cl
• Recent ClinicalTrials: Neurobiology of Eating Disorders Treatments
• Uses: Controlled Substance

Technology Process of Delorazepam

There total 20 articles about Delorazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5,2'-dichloro-2-(phtalimidoacetamido)benzophenone → delorazepam (2894-67-9)

Guidance literature:

With hydrazine hydrate; In methanol; at 60 ℃; for 3h;

DOI:10.1135/cccc19803593

Reference yield: 86.5%

2-chloroacetamido-2’,5-dichlorobenzophenone (14405-03-9) → delorazepam (2894-67-9)

Guidance literature:

With hexamethylenetetramine; ammonium acetate; In ethanol; for 6h; Reflux;

DOI:10.1021/op068009u

Reference yield: 82.0%

N,N'-methylenebis<3-(2'-o-chlorobenzoyl-4'-chloro)phenyl>-4-imidazolidinone (79988-55-9) → delorazepam (2894-67-9)

Guidance literature:

With ammonium hydroxide; In ethanol; Heating;

DOI:10.1002/jhet.5570180523

upstream raw materials:

N,N'-methylenebis<3-(2'-o-chlorobenzoyl-4'-chloro)phenyl>-4-imidazolidinone

7-chloro-5-(2-chlorophenyl)-2-ethoxy-3H-1,4-benzodiazepine

7-chloro-5-(2-chlorophenyl)-2-isopropoxy-3H-1,4-benzodiazepine

7-chloro-5-(2-chloro-phenyl)-2-methoxy-3H-benzo[e][1,4]diazepine

Downstream raw materials:

7-chloro-5-(2-chlorophenyl)-2-dimethylamino-3H-1,4-benzodiazepine

7-chloro-5-(2-chlorophenyl)-2-(2-dimethylaminoethylthio)-3H-1,4-benzodiazepine

1-benzyloxymethyl-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

7-Chloro-5-(2-chloro-phenyl)-2-propylsulfanyl-3H-benzo[e][1,4]diazepine

Refernces

• 1、 -. "Preparation method of lorazepam intermediate". . . Retrieved 2020/12/15.
• 2、 Cepanec, Ivica,Litvic, Mladen,Pogorelic, Ivan. "Efficient synthesis of 3-hydroxy-1,4-benzodiazepines oxazepam and lorazepam by new acetoxylation reaction of 3-position of 1,4-benzodiazepine ring". . p. 1192 - 1198. Retrieved 2012/12/23.