14405-03-9

Basic information

• Product Name: 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide
• Synonyms: 2'-(2-CHLOROBENZOYL)-2,4'-DICHLOROACETANILDE;2'-(2-CHLOROBENZOYL)-2,4'-DICHLORO-ACETANILIDE;2-(2-CHLOROACETAMIDO)-2',5-DICHLOROBENZOPHENONE;2-CHLOROACETAMIDO-2',5-DICHLOROBENZOPHENONE;2-CHLOROACETAMINO-2',5-DICHLOROBENZOPHENONE;2-CHLOROACETYLAMINO-2',5-DICHLOROBENZOPHENONE;2-CHLORO-N-[4-CHLORO-2-(2-CHLOROBENZOYL)PHENYL]ACETAMIDE;AKOS BBS-00003966
• CAS NO: 14405-03-9
• Molecular Formula: C₁₅H₁₀Cl₃NO₂
• Molecular Weight: 342.6
• EINECS: 238-376-5
• Product Categories: Aromatic Benzophenones & Derivatives (substituted)
• Mol File: 14405-03-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 159-161 °C(lit.)
• Boiling Point: 565 °C at 760 mmHg
• Flash Point: 295.5 °C
• Appearance: yellow solid.
• Density: 1.452 g/cm³
• Vapor Pressure: 8.66E-13mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: Refrigerator, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
• PKA: 11.29±0.70(Predicted)
• CAS DataBase Reference: 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide(14405-03-9)
• EPA Substance Registry System: 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide(14405-03-9)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• WGK Germany: 3
• Hazardous Substances Data: 14405-03-9(Hazardous Substances Data)

Usage

Uses

2-?Chloro-?N-?[4-?chloro-?2-?(2-?chlorobenzoyl)?phenyl]?acetamide is a potential anticancer agent and is used in the synthesis of 4-?Aryl-?6-?chloro-?quinolin-?2-?ones and 5-?Aryl-?7-?chloro-?1,?4-?benzodiazepines, anti-?hepatitis B virus compounds.

InChI:InChI=1/C15H10Cl3NO2/c16-8-14(20)19-13-6-5-9(17)7-11(13)15(21)10-3-1-2-4-12(10)18/h1-7H,8H2,(H,19,20)

Upstream product

• 106-47-8 4-chloro-aniline 
• 609-65-4 o-chlorobenzoyl chloride 
• 79-04-9 chloroacetyl chloride 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 

Downstream Products

• 79988-55-9 N,N'-methylenebis<3-(2'-o-chlorobenzoyl-4'-chloro)phenyl>-4-imidazolidinone 
• 612545-17-2 N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-2-[4-(6-chloro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidin-1-yl]-acetamide hydrochloride 
• 1065540-50-2 N₁-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-(4-(2-[4-chloro-2-(2-chlorobenzoyl)anilino]-2-oxoethyl)piperazino)acetamide 
• 1065540-38-6 N₁-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-[4-(2-pyrimidinyl)piperazino]acetamide 
• 1065540-41-1 N₁-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-[4-(4-quinazolinyl)piperazino]acetamide 
• 1065540-36-4 N₁-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-[4-(2-pyridyl)piperazino]acetamide 
• 1065540-33-1 N₁-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-[4-(2-methoxyphenyl)piperazino]acetamide 
• 2894-67-9 delorazepam 
• 1007385-86-5 (2S)-N-{4-{N₁-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-oxaacetamido}-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 59049-44-4 2-[Allyl-(2-cyano-ethyl)-amino]-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetamide 
• 2848-96-6 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate 
• 846-49-1 lorazepam 

Relevant articles and documents

Preparation method of lorazepam intermediate

The invention provides a preparation method of a lorazepam intermediate, the lorazepam intermediate is 7-chloro-5-(2-chlorphenyl)-1, 3-dihydro-2H-1, 4-benzodiazepin-2-one-4-oxide, and the preparationmethod comprises the following steps: (1) carrying out acylation reaction on 2-amino-2', 5-dichlorobenzophenone and chloroacetyl chloride to prepare 2-chloroacetamido-2', 5-dichlorobenzophenone, (2) reacting 2-chloroacetamido-2', 5-dichlorobenzophenone with urotropine and ammonium acetate to prepare 7-chloro-5-(2-chlorphenyl)-1, 3-dihydro-2H-1, 4-benzodiazepin-2-one, and (3) carrying out a reaction on the 7-chloro-5-(2-chlorphenyl)-1, 3-dihydro-2H-1, 4-benzodiazepin-2-one and ammonium acetate to obtain 7-chloro-5-(2-chlorphenyl)-1, 3-dihydro-2H-1, 4-benzodiazepin-2-one-4-oxide. The preparationmethod disclosed by the invention is simple and convenient, mild in reaction condition, high in yield, good in product quality and low in cost.

Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives

A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepine were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities for the first time. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. Compound 5c showed IC50 of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, respectively, which were 10 times higher than that of its analog 4c and led to better selective index (SI) values (SI = 23.2 and 3.4, respectively).