3-hydroxy-5,6-diMethylpyrazine-2-carboxaMide

Base Information

Chemical Name:3-hydroxy-5,6-diMethylpyrazine-2-carboxaMide
CAS No.:90000-71-8
Molecular Formula:C7H9N3O2
Molecular Weight:167.1653
Hs Code.:2934999090
Mol file:90000-71-8.mol

Synonyms:5,6-dimethyl-3-oxo-3,4-dihydropyrazine-2-carboxamide;5,6-dimethyl-3-oxo-3,4-dihydro-pyrazine-2-carboxylic acid amide;5,6-Dimethyl-3-oxo-3,4-dihydro-pyrazin-2-carbonsaeure-amid;

Suppliers and Price of 3-hydroxy-5,6-diMethylpyrazine-2-carboxaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5,6-Dimethyl-3-oxo-3,4-dihydropyrazine-2-carboxamide 95+%
1g
$ 772.00

Chemenu
5,6-dimethyl-3-oxo-3,4-dihydropyrazine-2-carboxamide 95%
1g
$ 729.00

American Custom Chemicals Corporation
5,6-DIMETHYL-3-OXO-3,4-DIHYDROPYRAZINE-2-CARBOXAMIDE 95.00%
5MG
$ 501.27

Alichem
5,6-Dimethyl-3-oxo-3,4-dihydropyrazine-2-carboxamide
1g
$ 640.56

Total 6 raw suppliers

Chemical Property of 3-hydroxy-5,6-diMethylpyrazine-2-carboxaMide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：88.84000
Density:1.44g/cm³
LogP:0.18590

Purity/Quality:

95+% ^*data from raw suppliers

5,6-Dimethyl-3-oxo-3,4-dihydropyrazine-2-carboxamide 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-Hydroxy-5,6-dimethylpyrazine-2-carboxamide is a building block related to Favipiravir(F103350). Favipiravir is used for the treatment of advanced Ebola virus infection in a small animal model. Favipiravir suppressed the replication of Zaire Ebola virus and prevented a lethal outcome in 100% of the animals. Based on the studies, Favipiravir can be a candidate for the treatment of Ebola hemorrhagic fever.

Technology Process of 3-hydroxy-5,6-diMethylpyrazine-2-carboxaMide

There total 1 articles about 3-hydroxy-5,6-diMethylpyrazine-2-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 62009-47-6
2-aminopropanediamide

: 431-03-8
dimethylglyoxal

: 90000-71-8
5,6-dimethyl-3-oxo-3,4-dihydropyrazine-2-carboxamide

Guidance literature:: With water monomer; sodium hydroxide; at 10 ℃; for 0.333333h;

Reference yield:

: 90000-71-8
5,6-dimethyl-3-oxo-3,4-dihydropyrazine-2-carboxamide

: 5,6-dimethyl-2-phenyl-1H-imidazo[4,5-b]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; aqueous KOH

2: POCl₃

3: water; copper-powder; NH₃

4: xylene

With potassium hydroxide; ammonia; water; bromine; copper; xylene; trichlorophosphate;
DOI:10.1021/ja01122a017

Reference yield:

: 90000-71-8
5,6-dimethyl-3-oxo-3,4-dihydropyrazine-2-carboxamide

: 39213-71-3
3-chloro-5,6-dimethyl-pyrazin-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; aqueous KOH

2: POCl₃

With potassium hydroxide; bromine; trichlorophosphate;
DOI:10.1021/ja01122a017