1-(Ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone

Base Information

Chemical Name:1-(Ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone
CAS No.:87532-78-3
Molecular Formula:C15H19NO4
Molecular Weight:277.3157
Hs Code.:2933399090
DSSTox Substance ID:DTXSID301007614
ChEMBL ID:CHEMBL305109
Mol file:87532-78-3.mol

Synonyms:1-(ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone;1-ECMPP

Suppliers and Price of 1-(Ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(Ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone

Chemical Property:

Vapor Pressure:1.02E-07mmHg at 25°C
Boiling Point:433.5°Cat760mmHg
Flash Point:216°C
PSA：55.84000
Density:1.19g/cm³
LogP:2.24510
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:277.13140809
Heavy Atom Count:20
Complexity:365

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)N1CCCC(C1=O)(C2=CC=CC=C2)OC

Technology Process of 1-(Ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone

There total 6 articles about 1-(Ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 541-41-3
chloroformic acid ethyl ester

: 87532-77-2
3-methoxy-3-phenyl-2-piperidinone

: 87532-78-3
1-(ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone

Guidance literature:: In toluene; for 7h; Heating;
DOI:10.1021/jm00368a017

Reference yield:

: 65379-04-6
4-cyano-2-phenyl-2-tetrahydropyran-2-yloxy-butyric acid ethyl ester

: 87532-78-3
1-(ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / 20percent aq. HCl / ethanol / 1 h / Heating

2: 1.) NaH / 1.) DME, RT, 30 min, 2.) DME, reflux, 1 h

3: 72 percent / H₂, glacial AcOH / PtO₂ / 7 h / 2430.6 Torr

4: 98 percent / toluene / 7 h / Heating

With hydrogenchloride; hydrogen; sodium hydride; acetic acid; platinum(IV) oxide; In ethanol; toluene;
DOI:10.1021/jm00368a017

Reference yield:

: 33224-90-7
ethyl α-methoxy-α-phenylacetate

: 87532-78-3
1-(ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DME, 2.) DME, RT, overnight

2: 72 percent / H₂, glacial AcOH / PtO₂ / 7 h / 2430.6 Torr

3: 98 percent / toluene / 7 h / Heating

With hydrogen; sodium hydride; acetic acid; platinum(IV) oxide; In toluene;
DOI:10.1021/jm00368a017