Technology Process of Benzoic acid, 2-hydroxy-4-[(4-nitrophenyl)methyl]-, phenylmethyl ester
There total 5 articles about Benzoic acid, 2-hydroxy-4-[(4-nitrophenyl)methyl]-, phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-hydroxy-4-(4-nitro-benzyl)-benzoic acid;
With
potassium hydroxide;
In
water;
benzyl bromide;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
DOI:10.1021/ja0677970
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 82 percent / N-bromosuccinimide; benzoyl peroxide / CCl4; H2O / 2 h / 75 °C
2.1: 87 percent / Na2CO3 / Pd(PPh3)4 / tetrahydrofuran; H2O / 3 h / Heating
3.1: 91 percent / trifluoroacetic acid; H2O / 12 h / 25 °C
4.1: KOH / H2O
4.2: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 24 h / 20 °C
With
potassium hydroxide; N-Bromosuccinimide; sodium carbonate; dibenzoyl peroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; tetrachloromethane; water; trifluoroacetic acid;
2.1: Suzuki cross-coupling reaction;
DOI:10.1021/ja0677970
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 87 percent / Na2CO3 / Pd(PPh3)4 / tetrahydrofuran; H2O / 3 h / Heating
2.1: 91 percent / trifluoroacetic acid; H2O / 12 h / 25 °C
3.1: KOH / H2O
3.2: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 24 h / 20 °C
With
potassium hydroxide; sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; water; trifluoroacetic acid;
1.1: Suzuki cross-coupling reaction;
DOI:10.1021/ja0677970
