2-BroMo-4-ethyl-5-nitro-pyridine

Base Information

• Chemical Name: 2-BroMo-4-ethyl-5-nitro-pyridine
• CAS No.: 929617-28-7
• Molecular Formula: C₇H₇BrN₂O₂
• Molecular Weight: 231.049
• Mol file: 929617-28-7.mol

Synonyms:2-bromanyl-4-ethyl-5-nitro-pyridine;S02-0030;2-Bromo-4-ethyl-5-nitro-pyridine;

Chemical Property of 2-BroMo-4-ethyl-5-nitro-pyridine

Chemical Property:

• PSA: 58.71000
• LogP: 2.83790

Purity/Quality:

95% ^*data from raw suppliers

2-Bromo-4-ethyl-5-nitro-pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-BroMo-4-ethyl-5-nitro-pyridine

There total 1 articles about 2-BroMo-4-ethyl-5-nitro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4-ethyl-5-nitropyridin-2-amine (70936-17-3) → 2-bromo-4-ethyl-5-nitro-pyridine (929617-28-7)

Guidance literature:

With hydrogen bromide; bromine; for 1.5h; cooling;

DOI:10.1016/j.bmc.2007.01.010

Reference yield: 90.0%

2-bromo-4-ethyl-5-nitro-pyridine (929617-28-7) → 6-bromo-4-ethylpyridin-3-ylamine (929617-29-8)

Guidance literature:

With hydrogen; nickel; In tetrahydrofuran; for 18h;

DOI:10.1016/j.bmc.2007.01.010

Reference yield:

2-bromo-4-ethyl-5-nitro-pyridine (929617-28-7) → 5-[5-(2-tert-butoxycarbonylamino-3-phenyl-propoxy)-pyridin-3-yl]-3-methyl-pyrazolo[3,4-c]pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / hydrogen / nickel / tetrahydrofuran / 18 h

2: acetic acid; sodium nitrite / H₂O / 24 h / 20 °C

3: 7.5 g / triethylamine; 4-(dimethylamino)pyridine / acetonitrile / 20 °C

4: cesium fluoride / bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / dioxane / 16 h / 80 °C

With dmap; hydrogen; acetic acid; triethylamine; cesium fluoride; sodium nitrite; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; nickel; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; 4: Stille reaction;

DOI:10.1016/j.bmc.2007.01.010

upstream raw materials:

4-ethyl-5-nitropyridin-2-amine

Downstream raw materials:

6-bromo-4-ethylpyridin-3-ylamine

5-bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine

Refernces