929617-29-8

Basic information

• Product Name: 6-BROMO-4-ETHYLPYRIDIN-3-AMINE
• Synonyms: 6-BROMO-4-ETHYLPYRIDIN-3-AMINE;6-BroMo-4-ethyl-3-pyridinaMine;6-Bromo-4-ethyl-pyridin-3-ylamine
• CAS NO: 929617-29-8
• Molecular Formula: C₇H₉BrN₂
• Molecular Weight: 201.06376
• Mol File: 929617-29-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-BROMO-4-ETHYLPYRIDIN-3-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-4-ETHYLPYRIDIN-3-AMINE(929617-29-8)
• EPA Substance Registry System: 6-BROMO-4-ETHYLPYRIDIN-3-AMINE(929617-29-8)

Safety Data

• Hazardous Substances Data: 929617-29-8(Hazardous Substances Data)

Usage

General Description

6-Bromo-4-ethylpyridin-3-amine is a chemical compound with the molecular formula C8H10BrN3. It is a derivative of pyridine, which is a common heterocyclic organic compound. This chemical is used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and other fine chemicals. Its structure contains a pyridine ring with a bromo substituent at the 6-position and an ethyl group at the 4-position, as well as an amine group at the 3-position. 6-BROMO-4-ETHYLPYRIDIN-3-AMINE has potential applications in various industries due to its versatile chemical properties.

Upstream product

• 70936-17-3 4-ethyl-5-nitropyridin-2-amine 
• 929617-28-7 2-bromo-4-ethyl-5-nitro-pyridine 

Downstream Products

• 929617-30-1 5-bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine 
• 1449516-24-8 6-cyclohexyl-4-ethylpyridin-3-ylamine 

Relevant articles and documents

Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt

Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.