(4-Cyclopropyl-1-piperazinyl)[4-[(4-fluoro-1-piperidinyl)methyl]phenyl]methanone

Base Information

Chemical Name:(4-Cyclopropyl-1-piperazinyl)[4-[(4-fluoro-1-piperidinyl)methyl]phenyl]methanone
CAS No.:929622-11-7
Molecular Formula:C20H28FN3O
Molecular Weight:345.46
Hs Code.:
ChEMBL ID:CHEMBL3577960
DSSTox Substance ID:DTXSID201134452

Synonyms:CHEMBL3577960;SCHEMBL1449310;DTXSID201134452;BDBM50089368;(4-Cyclopropyl-1-piperazinyl)[4-[(4-fluoro-1-piperidinyl)methyl]phenyl]methanone;929622-11-7

Suppliers and Price of (4-Cyclopropyl-1-piperazinyl)[4-[(4-fluoro-1-piperidinyl)methyl]phenyl]methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (4-Cyclopropyl-1-piperazinyl)[4-[(4-fluoro-1-piperidinyl)methyl]phenyl]methanone

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:345.22164069
Heavy Atom Count:25
Complexity:446

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC1N2CCN(CC2)C(=O)C3=CC=C(C=C3)CN4CCC(CC4)F

Technology Process of (4-Cyclopropyl-1-piperazinyl)[4-[(4-fluoro-1-piperidinyl)methyl]phenyl]methanone

There total 6 articles about (4-Cyclopropyl-1-piperazinyl)[4-[(4-fluoro-1-piperidinyl)methyl]phenyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929622-21-9
4-(4-cyclopropyl-piperazine-1-carbonyl)-benzaldehyde

: 78197-27-0
4-fluoropiperidine

: 929622-11-7
(4-cyclopropylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane;
DOI:10.1021/ml5005156

Reference yield:

: 1-cyclopropylpiperazine dihydrochloride

: 929622-11-7
(4-cyclopropylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ml5005156

Reference yield:

: 77278-34-3
4-cyclopropylpiperazine-1-carboxylic acid tert-butyl ester

: 929622-11-7
(4-cyclopropylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 9.17 h / 40 - 45 °C

2: sodium hydroxide / toluene; water / 5 - 20 °C

3: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; toluene;
DOI:10.1021/ml5005156