3-(Benzyloxy)propionic acid methyl ester

Base Information

• Chemical Name: 3-(Benzyloxy)propionic acid methyl ester
• CAS No.: 4126-60-7
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Hs Code.: 2918990090
• Mol file: 4126-60-7.mol

Synonyms:Methyl 3-(benzyloxy)propanoate;3-Benzyloxy-propionsaeure-methylester;Propionic acid,3-(benzyloxy)-,methyl ester;3-(benzyloxy)propanoic acid methyl ester;

Chemical Property of 3-(Benzyloxy)propionic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.00302mmHg at 25°C
• Boiling Point: 284.2°Cat760mmHg
• Flash Point: 98.6°C
• PSA: 35.53000
• Density: 1.069g/cm³
• LogP: 1.76630
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-(Benzyloxy)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Benzyloxy)propionic acid methyl ester

There total 9 articles about 3-(Benzyloxy)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C11H14N2O3 (1160845-83-9) → methyl β-benzyloxypropionate (4126-60-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In chloroform; for 24h; Reflux;

DOI:10.1016/j.tetlet.2009.03.118

Reference yield: 75.0%

3-benzyloxypropan-1-ol (4799-68-2) → methyl β-benzyloxypropionate (4126-60-7)

Guidance literature:

With bismuth(III) nitrate; tellurium; 5%-palladium/activated carbon; In methanol; at 50 ℃; for 12h; under 760.051 Torr; Temperature; Reagent/catalyst;

Reference yield: 75.0%

3-benzyloxypropan-1-ol (4799-68-2) + potassium methanolate (865-33-8) → methyl β-benzyloxypropionate (4126-60-7)

Guidance literature:

With tellurium; bismuth (III) nitrate pentahydrate; 5%-palladium/activated carbon; oxygen; In methanol; at 50 ℃; for 12h; under 760.051 Torr; Temperature; Reagent/catalyst; Catalytic behavior;

DOI:10.1021/ol402428e

upstream raw materials:

diazomethane

3-benzyloxypropan-1-ol

methanol

3-benzyloxypropionitrile

Downstream raw materials:

3-Benzyloxy-propionsaeure-benzylester

3-{2-[(phenylmethyl)oxy]ethyl}-1H-1,2,4-triazol-5-amine

7-chloro-5-methyl-2-{2-[(phenylmethyl)oxy]ethyl}[1,2,4]triazolo[1,5-a]pyrimidine

5-methyl-2-{2-[(phenylmethyl)oxy]ethyl}[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

Refernces

• 1、 Kim, Insu,Lee, Chulbom. "Rhodium-catalyzed oxygenative addition to terminal alkynes for the synthesis of esters, amides, and carboxylic acids". supporting information. p. 10023 - 10026. Retrieved 2013/10/01.
• 2、 González, Alfredo,Pérez, Daniel,Puig, Carles,Ryder, Hamish,Sanahuja, Jordi,Solé, Laia,Bach, Jordi. "Efficient three-step sequence for the deamination of α-aminoesters. Application to the synthesis of CysLT1 antagonists". supporting information; experimental part. p. 2750 - 2753. Retrieved 2009/09/25.