2-Hepten-6-ynoic acid, 7-phenyl-, ethyl ester, (2E)-

Base Information

• Chemical Name: 2-Hepten-6-ynoic acid, 7-phenyl-, ethyl ester, (2E)-
• CAS No.: 92994-36-0
• Molecular Formula: C15H16O2
• Molecular Weight: 228.291
• Mol file: 92994-36-0.mol

Synonyms:

Chemical Property of 2-Hepten-6-ynoic acid, 7-phenyl-, ethyl ester, (2E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hepten-6-ynoic acid, 7-phenyl-, ethyl ester, (2E)-

There total 6 articles about 2-Hepten-6-ynoic acid, 7-phenyl-, ethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-phenylpent-4-ynal (70214-59-4) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → ethyl (2E)-7-phenylhept-2-en-6-ynoate (92994-36-0)

Guidance literature:

In dichloromethane; at 55 ℃; for 23h; Inert atmosphere;

DOI:10.1039/d1cc01166a

Reference yield:

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 5-phenylpent-4-ynal (70214-59-4) → ethyl (2E)-7-phenylhept-2-en-6-ynoate (92994-36-0)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; for 1h; Inert atmosphere;

5-phenylpent-4-ynal; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2014.06.020

Reference yield:

iodobenzene (591-50-4) → ethyl (2E)-7-phenylhept-2-en-6-ynoate (92994-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NHEt₂ / (Ph₃P)2PdCl₂-CuI

2: PCC / CH₂Cl₂

3: CH₂Cl₂

With diethylamine; pyridinium chlorochromate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane;

DOI:10.1016/S0040-4039(00)96405-0

upstream raw materials:

5-phenylpent-4-ynal

ethyl (triphenylphosphoranylidene)acetate

iodobenzene

pent-1-yn-5-ol

Downstream raw materials:

(E)-7-phenylhept-2-en-6-ynal

(2E,4E,8Z)-9-Phenyl-nona-2,4,8-trienoic acid isobutyl-amide

N-isobutyl-9-phenylnona-2E,4E-dien-8-ynamide

7-phenylhept-2E-en-6-ynoic acid