70214-59-4

Upstream product

• 24595-58-2 5-phenylpent-4-yn-1-ol 
• 536-74-3 phenylacetylene 
• 107-02-8 acrolein 
• 591-50-4 iodobenzene 
• 5390-04-5 pent-1-yn-5-ol 
• 17733-79-8 (E)-5-phenyl-penta-2-ene-4-yne-1-ol 
• 30625-91-3 (E)-5-phenylpent-2-en-4-ynal 
• 27948-27-2 (E)-methyl 5-phenylpent-2-en-4-ynoate 
• 2579-22-8 Phenylpropargyl aldehyde 
• 108-86-1 bromobenzene 
• 1276664-59-5 (5,5-diethoxypent-1-yn-1-yl)benzene 
• 4440-01-1 lithium phenylacetylide 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 

Downstream Products

• 130066-05-6 2-(1-Hydroxy-5-phenyl-pent-4-ynyl)-2-methyl-cyclohexanone 
• 130066-06-7 2-(1-Hydroxy-5-phenyl-pent-4-ynyl)-2-methyl-cycloheptanone 
• 130066-09-0 2-(1-Hydroxy-5-phenyl-pent-4-ynyl)-2-methyl-cyclopentanone 
• 92993-97-0 N-isobutyl-7-phenylhept-2E-en-6-ynamide 
• 92994-36-0 ethyl (2E)-7-phenylhept-2-en-6-ynoate 
• 24595-57-1 6-phenyl-5-hexyn-2-ol 

Relevant academic research and scientific papers

Method for efficiently synthesizing 1,6-diene-3-ketone derivatives

The invention discloses a method for efficiently synthesizing 1,6-diene-3-ketone derivatives, which comprises the following steps: in an organic solvent system, taking a compound represented by a formula 2 as a raw material, carrying out stirring reflux r

Enantioselective nickel-catalyzedanti-arylmetallative cyclizations onto acyclic electron-deficient alkenes

Enantioselective nickel-catalyzed reactions of (hetero)arylboronic acids or alkenylboronic acids with substrates containing an alkyne tethered to various acyclic electron-deficient alkenes are described.

Chemoselective Biohydrogenation of Alkenes in the Presence of Alkynes for the Homologation of 2-Alkynals/3-Alkyn-2-ones into 4-Alkynals/Alkynols

The chemoselective hydrogenation of alkenes in the presence of alkynes is a very challenging transformation to achieve with traditional chemical methods. The development of an effective procedure to perform this transformation would enrich the tool-kit available to organic chemists for the development of useful synthetic routes, and the creation of novel structural motifs. The reduction of activated alkene bonds by ene-reductases (ERs) is completely chemoselective, because of the mechanism of the reaction. Thus, we investigated the use of ERs belonging to the Old Yellow Enzyme family for the reduction of α,β-unsaturated aldehydes with a conjugated C≡C triple bond at the γ position. This reaction was exploited as the key step for the development of an effective homologation route to convert aryl and alkyl substituted propynals and butynones into 4-alkynals and 4-alkynols, avoiding some troublesome or hazardous steps of known synthetic routes. (Figure presented.).

Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1

The orphan nuclear receptor Liver Receptor Homologue-1 (LRH-1) is an emerging drug target for metabolic disorders. The most effective known LRH-1 modulators are phospholipids or synthetic hexahydropentalene compounds. While both classes have micromolar ef

MODULATORS OF LIVER RECEPTOR HOMOLOGUE 1 (LRH-1) AND USES

This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure r

METHOD FOR SYNTHESIZING NOVEL COMPOUNDS DERIVED FROM 3-HYDROXY-CYCLOPENTYL ACETIC ACID

The present invention relates to compounds of formula (I): in which R1 is a hydrogen atom, a phenyl radical, or a straight or branched, saturated or unsaturated hydrocarbon radical having 1 to 8 carbon atoms.

K2CO3-Mediated Cyclization and Rearrangement of γ,δ-Alkynyl Oximes to Form Pyridols

A novel K2CO3-mediated cyclization and rearrangement of γ,δ-alkynyl oximes for the synthesis of pyridols is described. The process accomplishes an efficient [1,3] rearrangement of the O-vinyl oxime intermediate which is in situ generated from the intramolecular nucleophilic addition of γ,δ-alkynyl oximes. The reaction employs readily accessible starting materials, tolerates a wide range of functional groups, and gives a variety of synthetically challenging pyridols in good yields.

Palladium-catalysed atom-economical synthesis of conjugated dienals from terminal acetylenes and acrolein

Conjugated (E,E)-dienals are versatile synthetic intermediates owing to their trifunctional, electrophilic nature and the prevalence of the (E,E)-diene in a wide range of functional molecules. It is shown herein that (E,E)-dienals can be readily prepared

Cyclization of alk-4-ynals with o-diaminoarenes as a selective one-pot synthesis of arylmethylidene-substituted 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazoles and 7,8-dihydro-6H-pyrrolo[1’,2’:1,2]imidazo[4,5-b]pyridines

A one-pot synthesis of arylmethylidene-substituted 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazoles based on the reaction of alk-4-ynals with 1,2-diaminobenzenes in DMSO at sequential catalysis with NH4Br and bases was suggested. The use in these pr

Palladium-catalyzed 1,4-addition of terminal alkynes to acrolein

Abstract A Pd(OAc)2-PMe3 catalyzed 1,4-addition of terminal alkynes to acrolein has been developed with an environmentally conscious methodology on water. The reaction conditions were optimized to favor 1,4-addition over acrolein polymerization. The scope of the reaction was explored as well as its performance in acetone. A wide variety of 4-alkynals were obtained in moderate to good yields, thus showing the versatility of this reaction.