4-Amino-5-(2-phenylethyl)-4H-1,2,4-triazole-3-thiol

Base Information

• Chemical Name: 4-Amino-5-(2-phenylethyl)-4H-1,2,4-triazole-3-thiol
• CAS No.: 93073-17-7
• Molecular Formula: C10H12N4S
• Molecular Weight: 220.298
• Mol file: 93073-17-7.mol

Synonyms:4-Amino-5-phenethyl-4H-[1,2,4]triazole-3-thiol;4-amino-3-{1-(2-phenyl)-ethyl}-5-mercapto[4H]-1,24-triazole;4-amino-5-phenethyl-4H-1,2,4-triazole-3-thiol;

Chemical Property of 4-Amino-5-(2-phenylethyl)-4H-1,2,4-triazole-3-thiol

Chemical Property:

• Melting Point: 160 - 162 °C (ethanol)
• PSA: 95.53000
• LogP: 1.64700

Purity/Quality:

98%min ^*data from raw suppliers

4-amino-5-(2-phenylethyl)-4H-1,2,4-triazole-3-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Amino-5-(2-phenylethyl)-4H-1,2,4-triazole-3-thiol

There total 4 articles about 4-Amino-5-(2-phenylethyl)-4H-1,2,4-triazole-3-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Thiocarbohydrazide (2231-57-4) + 3-Phenylpropionic acid (501-52-0) → 5-(2-phenethyl)-4-amino-1,2,4-triazole-3-thiol (93073-17-7)

Guidance literature:

at 160 - 170 ℃; for 0.25h;

Reference yield: 83.0%

5-(2-phenylethyl)-1,3,4-oxadiazole-2-thiol (93073-40-6) → 5-(2-phenethyl)-4-amino-1,2,4-triazole-3-thiol (93073-17-7)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

Reference yield:

3-Phenylpropionic acid (501-52-0) → 5-(2-phenethyl)-4-amino-1,2,4-triazole-3-thiol (93073-17-7)

Guidance literature:

Multi-step reaction with 4 steps

1: Acidic conditions

2: hydrazine hydrate

3: potassium hydroxide

4: hydrazine hydrate

With hydrazine hydrate; potassium hydroxide;

DOI:10.3390/molecules16021297

upstream raw materials:

5-(2-phenylethyl)-1,3,4-oxadiazole-2-thiol

Thiocarbohydrazide

3-Phenylpropionic acid

3-phenylpropanoic acid methyl ester

Downstream raw materials:

6-(4-Chloro-phenyl)-3-phenethyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole