3-(4-Chlorobenzoyl)-1-phenylpentane-1,4-dione

Base Information

• Chemical Name: 3-(4-Chlorobenzoyl)-1-phenylpentane-1,4-dione
• CAS No.: 93078-47-8
• Molecular Formula: C₁₈H₁₅ClO₃
• Molecular Weight: 314.768
• DSSTox Substance ID: DTXSID10536946
• Mol file: 93078-47-8.mol

Synonyms:3-(4-Chlorobenzoyl)-1-phenylpentane-1,4-dione;93078-47-8;DTXSID10536946

Chemical Property of 3-(4-Chlorobenzoyl)-1-phenylpentane-1,4-dione

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 314.0709720
• Heavy Atom Count: 22
• Complexity: 418

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C(CC(=O)C1=CC=CC=C1)C(=O)C2=CC=C(C=C2)Cl

Technology Process of 3-(4-Chlorobenzoyl)-1-phenylpentane-1,4-dione

There total 2 articles about 3-(4-Chlorobenzoyl)-1-phenylpentane-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

chloro-4 benzoylacetone sodee + α-bromoacetophenone (70-11-1) → (chloro-4-benzoyl)-3-phenyl-1-pentanedione-1,4 (93078-47-8)

Guidance literature:

In isopropyl alcohol; for 10h; Heating;

Reference yield:

1-(4'-chlorophenyl)-1,3-butanedione (6302-55-2) → (chloro-4-benzoyl)-3-phenyl-1-pentanedione-1,4 (93078-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / sodium / ethanol

2: 54 percent / propan-2-ol / 10 h / Heating

With sodium; In ethanol; isopropyl alcohol;

Reference yield: 62.0%

4-chloro-aniline (106-47-8) + (chloro-4-benzoyl)-3-phenyl-1-pentanedione-1,4 (93078-47-8) → (chloro-4-phenyl)-1-methyl-2-(chloro-4-benzoyl)-3-phenyl-5-pyrrole

Guidance literature:

for 3h; Heating;

upstream raw materials:

α-bromoacetophenone

1-(4'-chlorophenyl)-1,3-butanedione