1(2H)-Isoquinolinone, 3,4-diphenyl-

Base Information

• Chemical Name: 1(2H)-Isoquinolinone, 3,4-diphenyl-
• CAS No.: 93119-96-1
• Molecular Formula: C21H15NO
• Molecular Weight: 297.356
• Mol file: 93119-96-1.mol

Synonyms:

Chemical Property of 1(2H)-Isoquinolinone, 3,4-diphenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1(2H)-Isoquinolinone, 3,4-diphenyl-

There total 65 articles about 1(2H)-Isoquinolinone, 3,4-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-((2,6-difluorophenyl)sulfonyl)benzamide + diphenyl acetylene (501-65-5) → 3,4-diphenyl-2H-isoquinolin-1-one (93119-96-1)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 3,5-dinitrobenzoic acid potassium salt; In tert-butyl alcohol; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201601582

Reference yield: 96.0%

N-(pivaloyloxy)benzamide (61650-22-4) + diphenyl acetylene (501-65-5) → 3,4-diphenyl-2H-isoquinolin-1-one (93119-96-1)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In methanol; at 20 ℃; for 16h;

DOI:10.1021/ja201143v

Reference yield: 95.0%

diphenyl acetylene (501-65-5) + 3-phenyl-5H-1,4,2-dioxazol-5-one (19226-36-9) → 3,4-diphenyl-2H-isoquinolin-1-one (93119-96-1)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; potassium acetate; In methanol; at 20 ℃; for 0.0833333h; Temperature; Reagent/catalyst; Time; Catalytic behavior;

DOI:10.1016/j.tet.2019.04.054

upstream raw materials:

2-(α'-chloro-stilben-α-yl)-benzoic acid amide

potassium cyanate

Triphenylvinyl bromide

N-methoxybenzamide

Downstream raw materials:

5,6,13-triphenyl-8H-isoquinolino[3,2-a]isoquinolin-8-one

C₂₆H₁₈N₂O₃

C₂₈H₂₅NO₃

C₂₈H₂₅NO₃

Refernces

• 1、 Jiang, Jinyuan,Liu, Jidan,Liu, Zhao-Qing,Tian, Xin,Yang, Zhenke,Zheng, Jieying,Zheng, Liyao. "Rhodium(iii)-catalyzed oxidative annulation of isoquinolones with allyl alcohols: synthesis of isoindolo[2,1-b]isoquinolin-5(7H)-ones". supporting information. p. 339 - 344. Retrieved 2022/01/20.
• 2、 Barranco, Sergio,Benet-Buchholz, Jordi,Martínez de Salinas, Sara,Odena, Carlota,Pérez-Temprano, Mónica H.,Sanjosé-Orduna, Jesús. "Weakly Coordinated Cobaltacycles: Trapping Catalytically Competent Intermediates in Cp*CoIII Catalysis". supporting information. p. 6239 - 6243. Retrieved 2020/02/27.