N-MethoxybenzaMide

Base Information

• Chemical Name: N-MethoxybenzaMide
• CAS No.: 2446-51-7
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.165
• Mol file: 2446-51-7.mol

Synonyms:methyl benzohydroxamate;PhC(O)NH(OMe);Benzamide,N-methoxy;Y8417;N-methoxy-benzamide;O-methylbenzohydroxamic acid;

Chemical Property of N-MethoxybenzaMide

Chemical Property:

• Melting Point: 63.5-64.5 °C
• PSA: 41.82000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 1.55260

Purity/Quality:

≥95% ^*data from raw suppliers

N-Methoxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-MethoxybenzaMide

There total 36 articles about N-MethoxybenzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-methoxylamine hydrochloride (593-56-6) + benzoyl chloride (98-88-4) → N-methoxybenzamide (2446-51-7)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2004.02.048

Reference yield: 99.0%

N-methoxylamine hydrochloride (593-56-6) + benzoic acid (65-85-0,8013-63-6) → N-methoxybenzamide (2446-51-7)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/c9cc07173c

Reference yield: 91.0%

sodium benzoate (532-32-1) + N-methoxylamine hydrochloride (593-56-6) → N-methoxybenzamide (2446-51-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; acetonitrile; at 20 ℃; for 0.5h; Reagent/catalyst; Solvent; Green chemistry;

DOI:10.1039/d1ob02064a

upstream raw materials:

Ethyl (E)-O-Methylbenzohydroximate

Benzohydroxamic acid

methyl iodide

methyl bromide

Downstream raw materials:

benzamide

O-methyl N-chlorobenzohydroxamate

benzoic acid

2-propenyl (Z)-N-methoxybenzimidate

Refernces

• 1、 Tóth, Balázs L.,Sályi, Gerg?,Domján, Attila,Egyed, Orsolya,Bényei, Attila,Gonda, Zsombor,Novák, Zoltán. "Z-Selective Fluoroalkenylation of (Hetero)Aromatic Systems by Iodonium Reagents in Palladium-Catalyzed Directed C?H Activation". supporting information. p. 348 - 354. Retrieved 2021/11/09.
• 2、 Wang, Huihong,Cao, Fei,Gao, Weiwei,Wang, Xiaodong,Yang, Yuhang,Shi, Tao,Wang, Zhen. "Pd(II)-catalyzed annulation reactions of epoxides with benzamides to synthesize isoquinolones". supporting information. p. 863 - 868. Retrieved 2021/02/06.