4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid

Base Information

• Chemical Name: 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid
• CAS No.: 93178-73-5
• Molecular Formula: C14H14N2O2
• Molecular Weight: 242.277
• ChEMBL ID: CHEMBL163413
• DSSTox Substance ID: DTXSID80546774
• Nikkaji Number: J374.223G
• Mol file: 93178-73-5.mol

Synonyms:93178-73-5;4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid;CHEMBL163413;SCHEMBL2350719;DTXSID80546774;KLIYHHIBTVVFPB-UHFFFAOYSA-N;BDBM50008730;5-(p-Carboxyphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine;5-p-carboxyphenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine;4-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-5-yl)-benzoic acid;5-(p-Carboxyphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyridine

Chemical Property of 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 242.105527694
• Heavy Atom Count: 18
• Complexity: 313

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C(=O)O

Technology Process of 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid

There total 7 articles about 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-<4-(ethoxycarbonyl)phenyl>-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine hydrochloride (93178-72-4) → 5-(4-carboxyphenyl)-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine (93178-73-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1021/jm00106a038

Reference yield:

ethyl 4-(2-pyridinyl)benzoate (4385-61-9) → 5-(4-carboxyphenyl)-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine (93178-73-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 40percent peracetic acid / 3 h / 90 °C

2: 1.) dimethyl sulfate / 1.) toluene, 90 deg C, 3 h, 2.) water, 0 deg C, 24 h

3: 65 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 760 Torr

4: 83 percent / 15 h / 90 °C

5: 73 percent / POCl₃ / toluene / 15 h / 90 °C

6: 85 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr

7: 95 percent / 1 N NaOH / ethanol / 3 h / Heating

With hydrogenchloride; peracetic acid; sodium hydroxide; hydrogen; dimethyl sulfate; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; toluene;

DOI:10.1021/jm00106a038

Reference yield:

2-<4-(ethoxycarbonyl)phenyl>pyridine N-oxide (102676-38-0) → 5-(4-carboxyphenyl)-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine (93178-73-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) dimethyl sulfate / 1.) toluene, 90 deg C, 3 h, 2.) water, 0 deg C, 24 h

2: 65 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 760 Torr

3: 83 percent / 15 h / 90 °C

4: 73 percent / POCl₃ / toluene / 15 h / 90 °C

5: 85 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr

6: 95 percent / 1 N NaOH / ethanol / 3 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; dimethyl sulfate; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; toluene;

DOI:10.1021/jm00106a038

upstream raw materials:

5-<4-(ethoxycarbonyl)phenyl>-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine hydrochloride

ethyl 4-(2-pyridinyl)benzoate

2-<4-(ethoxycarbonyl)phenyl>pyridine N-oxide

6-(aminomethyl)-2-<4-(ethoxycarbonyl)phenyl>pyridine

Downstream raw materials:

5-(4-carbamylphenyl)-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine

fadrozole