(2R,4S)-METHYL 2-TERT-BUTYL-3-FORMYLOXAZOLIDINE-4-CARBOXYLATE

Base Information

• Chemical Name: (2R,4S)-METHYL 2-TERT-BUTYL-3-FORMYLOXAZOLIDINE-4-CARBOXYLATE
• CAS No.: 93250-91-0
• Molecular Formula: C10H17NO4
• Molecular Weight: 215.249
• Hs Code.: 2934999090
• Mol file: 93250-91-0.mol

Synonyms:4-Oxazolidinecarboxylic acid, 2-(1,1-dimethylethyl)-3-formyl-, methyl ester, (2R-cis)-;Methyl (2R,4S)-2-tert-butyl-3-formyloxazolidine-4-carboxylate;(2R,4S)-methyl2-tert-butyl-3-formyloxazolidine-4-carboxylate;

Chemical Property of (2R,4S)-METHYL 2-TERT-BUTYL-3-FORMYLOXAZOLIDINE-4-CARBOXYLATE

Chemical Property:

• Boiling Point: 318.2±42.0 °C (760 mmHg)
• PSA: 55.84000
• Density: 1.187±0.06 g/cm3(20 °C , 760mmHg)
• LogP: 0.96260

Purity/Quality:

(2R,4S)-METHYL-2-TERT-BUTYL-3-FORMYLOXAZOLIDINE-4-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,4S)-METHYL 2-TERT-BUTYL-3-FORMYLOXAZOLIDINE-4-CARBOXYLATE

There total 4 articles about (2R,4S)-METHYL 2-TERT-BUTYL-3-FORMYLOXAZOLIDINE-4-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pivalaldehyde (630-19-3) → (2R,4S)-2-tert-butyl-3-formyl-1,3-oxazolidine-4-carboxylic acid methyl ester (93250-91-0,131233-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / pentane / 16 h / Heating

2: diethyl ether / 6 h / 0 °C

With triethylamine; In diethyl ether; pentane;

DOI:10.1002/hlca.19870700426

Reference yield:

(2RS,5S)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine (190080-34-3) + formyl acetic anhydride (2258-42-6) → methyl (2S,4S)-2-tert-butyl-3-formyl-oxazolidine-4-carboxylate (93250-92-1,131233-89-1) + (2R,4S)-2-tert-butyl-3-formyl-1,3-oxazolidine-4-carboxylic acid methyl ester (93250-91-0,131233-89-1)

Guidance literature:

In diethyl ether; Yield given. Yields of byproduct given;

DOI:10.1002/hlca.19870700426

Reference yield:

methyl (2R,4S)-2-(tert-butyl)-1,3-oxazolane-4-carboxylate (93250-89-6,93250-90-9) + formyl acetic anhydride (2258-42-6) → (2R,4S)-2-tert-butyl-3-formyl-1,3-oxazolidine-4-carboxylic acid methyl ester (93250-91-0,131233-89-1)

Guidance literature:

Yield given;

DOI:10.1016/S0040-4039(01)81227-2

upstream raw materials:

methyl (2R,4S)-2-(tert-butyl)-1,3-oxazolane-4-carboxylate

formyl acetic anhydride

(2RS,5S)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine

pivalaldehyde

Downstream raw materials:

(2R,4S)-methyl 4-benzyl-2-tert-butyl-3-formyloxazolidine-4-carboxylate

(2R,4R)-2-tert-Butyl-3-formyl-4-(hydroxy-phenyl-methyl)-oxazolidine-4-carboxylic acid methyl ester

(2R,4S)-4-But-3-enyl-2-tert-butyl-3-formyl-oxazolidine-4-carboxylic acid methyl ester

(2R,4R)-4-Allyl-4-benzyloxymethyl-2-tert-butyl-oxazolidine-3-carbaldehyde

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