L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-, 2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-L-leucyl] hydrazide

Base Information

• Chemical Name: L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-, 2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-L-leucyl] hydrazide
• CAS No.: 93302-22-8
• Molecular Formula: C44H66N8O10
• Molecular Weight: 867.056
• Mol file: 93302-22-8.mol

Synonyms:

Chemical Property of L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-, 2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-L-leucyl] hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-, 2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-L-leucyl] hydrazide

There total 19 articles about L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-, 2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-L-leucyl] hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(tBOC-Gly-ΔPhe-(S)-Leu-NH-)2 (93199-90-7) → ({(S)-1-[(S)-1-(N'-{(S)-2-[(S)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamic acid tert-butyl ester (93302-22-8)

Guidance literature:

With hydrogen; <((-)BPPM)Rh(norbornadiene)>(1+)*ClO4(1-); In ethanol; at 40 ℃; under 7600 Torr;

DOI:10.1016/S0040-4020(01)82412-1

Reference yield:

(tBOC-Gly-ΔPhe-(S)-Leu-NH-)2 (93199-90-7) → ({(R)-1-[(S)-1-(N'-{(S)-2-[(R)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamic acid tert-butyl ester (93200-10-3,93302-22-8) + ({(S)-1-[(S)-1-(N'-{(S)-2-[(S)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamic acid tert-butyl ester (93302-22-8)

Guidance literature:

With hydrogen; <((-)BPPM)Rh(norbornadiene)>(1+)*ClO4(1-); In ethanol; at 40 ℃; under 7600 Torr;

DOI:10.1016/S0040-4020(01)82412-1

Reference yield:

(tBOC-Gly-ΔPhe-(S)-Leu-NH-)2 (93199-90-7) → ({(R)-1-[(S)-1-(N'-{(S)-2-[(R)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamic acid tert-butyl ester (93200-10-3,93302-22-8) + ({(S)-1-[(S)-1-(N'-{(S)-2-[(S)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamic acid tert-butyl ester (93302-22-8)

Guidance literature:

With hydrogen; <((-)BPPM)Rh(norbornadiene)>(1+)*ClO4(1-); In ethanol; at 40 ℃; under 7600 Torr;

DOI:10.1016/S0040-4020(01)82412-1

upstream raw materials:

(^tBOC-Gly-ΔPhe-(S)-Leu-NH-)2

BOC-glycine

(d,l)-phenylserine ethyl ester hydrochloride

Boc-Gly-Δ^ZPhe azlactone