Ethyl 2-amino-3-hydroxy-3-phenylpropanoate hydrochloride

Base Information

• Chemical Name: Ethyl 2-amino-3-hydroxy-3-phenylpropanoate hydrochloride
• CAS No.: 42267-16-3
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.2417
• NSC Number: 19569
• Mol file: 42267-16-3.mol

Synonyms:42267-16-3;ethyl 2-amino-3-hydroxy-3-phenylpropanoate hydrochloride;2-Amino-3-hydroxy-3-phenyl-propionic acid ethyl ester hydrochloride;ethyl 2-amino-3-hydroxy-3-phenylpropanoate;hydrochloride;2-AMINO-3-HYDROXY-3-PHENYL-PROPIONIC ACID ETHYLESTER HYDROCHLORIDE;NSC19569;NSC-19569;AKOS015847361;AS-83843;CS-0259308;E77731;EN300-729492;ethyl2-amino-3-hydroxy-3-phenylpropanoatehydrochloride

Chemical Property of Ethyl 2-amino-3-hydroxy-3-phenylpropanoate hydrochloride

Chemical Property:

• Vapor Pressure: 9.76E-06mmHg at 25°C
• Melting Point: 137.5-139 °C(Solv: ethanol (64-17-5))
• Boiling Point: 357.7°C at 760 mmHg
• Flash Point: 170.1°C
• PSA: 72.55000
• Density: 1.178g/cm³
• LogP: 2.11270
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 245.0818711
• Heavy Atom Count: 16
• Complexity: 202

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-3-hydroxy-3-phenyl-propionic acid ethylester hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C(C1=CC=CC=C1)O)N.Cl

Technology Process of Ethyl 2-amino-3-hydroxy-3-phenylpropanoate hydrochloride

There total 4 articles about Ethyl 2-amino-3-hydroxy-3-phenylpropanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

ethanol (64-17-5) + dl-threo-phenylserine (69-96-5,1078-17-7,2584-74-9,2584-75-0,6254-48-4,7352-06-9,7687-36-7,7695-56-9,32946-42-2,50897-27-3,68296-26-4,109120-55-0) → threo-DL-β-phenylserine ethyl ester hydrochloride (42267-16-3,64951-86-6,64999-32-2,93302-21-7)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

DOI:10.1055/s-2005-865285

Reference yield: 18.0%

glycine ethyl ester hydrochloride (623-33-6) + benzaldehyde (100-52-7) → threo-DL-β-phenylserine ethyl ester hydrochloride (42267-16-3,64951-86-6,64999-32-2,93302-21-7)

Guidance literature:

With triethylamine; In methanol; for 72h;

DOI:10.1016/S0040-4020(01)90519-8

Reference yield:

→ (d,l)-phenylserine ethyl ester hydrochloride (42267-16-3)

Guidance literature:

bei der Spaltung durch Hefemacerationssaft und anschliessenden Veresterung der Reaktionsprodukte mit alkoh. Salzsaeure;

upstream raw materials:

glycine ethyl ester hydrochloride

benzaldehyde

ethanol

dl-threo-phenylserine

Downstream raw materials:

(2RS,3SR)-2-amino-3-chloro-3-phenyl-propionic acid ethyl ester; hydrochloride

ethyl trans-4,5-dihydro-2,5-diphenyl-4-oxazolecarboxylate

(2S,3R)-2-Butyrylamino-3-hydroxy-3-phenyl-propionic acid ethyl ester

(+/-)-threo-2-amino-1-phenyl-1,3-propanediol

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