Benzenemethanol, 4,5-dichloro-2-(phenylthio)-

Base Information

• Chemical Name: Benzenemethanol, 4,5-dichloro-2-(phenylthio)-
• CAS No.: 93361-98-9
• Molecular Formula: C13H10Cl2OS
• Molecular Weight: 285.194
• Mol file: 93361-98-9.mol

Synonyms:

Chemical Property of Benzenemethanol, 4,5-dichloro-2-(phenylthio)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanol, 4,5-dichloro-2-(phenylthio)-

There total 7 articles about Benzenemethanol, 4,5-dichloro-2-(phenylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4,5-dichloro-2-(phenylthio)benzoic acid (93361-97-8) → 4,5-dichloro-2-(phenylthio)benzyl alcohol (93361-98-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; 1)stirred 3h 2)stand overnight;

DOI:10.1135/cccc19840992

Reference yield:

4-bromo-1,2-dichlorobenzene (18282-59-2) → 4,5-dichloro-2-(phenylthio)benzyl alcohol (93361-98-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 99percentHNO₃+H₂SO₄ / 3 h / 40 - 45 °C

2: 67 percent / NH₄Cl,Fe / ethanol; H₂O / 20 h / Heating

3: NaNO₂, H₂SO₄, CuCl, KCN, Na₂CO₃ / 1)H₂SO₄,NaNO₂,CH₃COOH 10 deg C, 30 min 2) KCN,Na₂CO₃ in water 2h,20 deg C 3)3h,85 deg C

4: 61 percent / H₂SO₄ / acetic acid; H₂O / 16 h / Heating

5: 94 percent / K₂CO₃,Cu,CuI / various solvent(s) / 7 h / Heating

6: 69 percent / sodium dihydrobis(2-methoxyethoxy)aluminate / benzene / 15 °C / 1.stirred 3h 2.stand overnight

With potassium cyanide; copper(l) iodide; sulfuric acid; nitric acid; iron; copper; sodium carbonate; potassium carbonate; ammonium chloride; copper(l) chloride; sodium nitrite; sodium bis(2-methoxyethoxy)aluminium dihydride; In ethanol; water; acetic acid; benzene;

DOI:10.1135/cccc19840992

Reference yield:

2-bromo-4,5-dichloroaniline (1940-30-3) → 4,5-dichloro-2-(phenylthio)benzyl alcohol (93361-98-9)

Guidance literature:

Multi-step reaction with 4 steps

1: NaNO₂, H₂SO₄, CuCl, KCN, Na₂CO₃ / 1)H₂SO₄,NaNO₂,CH₃COOH 10 deg C, 30 min 2) KCN,Na₂CO₃ in water 2h,20 deg C 3)3h,85 deg C

2: 61 percent / H₂SO₄ / acetic acid; H₂O / 16 h / Heating

3: 94 percent / K₂CO₃,Cu,CuI / various solvent(s) / 7 h / Heating

4: 69 percent / sodium dihydrobis(2-methoxyethoxy)aluminate / benzene / 15 °C / 1.stirred 3h 2.stand overnight

With potassium cyanide; copper(l) iodide; sulfuric acid; copper; sodium carbonate; potassium carbonate; copper(l) chloride; sodium nitrite; sodium bis(2-methoxyethoxy)aluminium dihydride; In water; acetic acid; benzene;

DOI:10.1135/cccc19840992

upstream raw materials:

4,5-dichloro-2-(phenylthio)benzoic acid

4-bromo-1,2-dichlorobenzene

2-bromo-4,5-dichloroaniline

1-bromo-4,5-dichloro-2-nitrobenzene

Downstream raw materials:

<4,5-dichloro-2-(phenylthio)phenyl>acetic acid

(4,5-Dichloro-2-phenylsulfanyl-phenyl)-acetonitrile