N-Acetyl-4,4'-diaminodiphenylmethane

Base Information

• Chemical Name: N-Acetyl-4,4'-diaminodiphenylmethane
• CAS No.: 24367-94-0
• Molecular Formula: C15H16 N2 O
• Molecular Weight: 240.305
• Hs Code.: 2924299090
• NSC Number: 109735
• DSSTox Substance ID: DTXSID00179109
• Nikkaji Number: J650.074I
• Wikidata: Q83049623
• Mol file: 24367-94-0.mol

Synonyms:acetyl-MDA;N-acetyl-4,4'-diaminodiphenylmethane;N-acetyl-4,4'-methylenedianiline;N-acetyl-DDM

Chemical Property of N-Acetyl-4,4'-diaminodiphenylmethane

Chemical Property:

• Vapor Pressure: 2.08E-09mmHg at 25°C
• Boiling Point: 481°Cat760mmHg
• Flash Point: 244.7°C
• PSA: 55.12000
• Density: 1.176g/cm³
• LogP: 3.47220
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 240.126263138
• Heavy Atom Count: 18
• Complexity: 264

Purity/Quality:

97% ^*data from raw suppliers

N-AcetylMethylenedianiline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)N

Technology Process of N-Acetyl-4,4'-diaminodiphenylmethane

There total 6 articles about N-Acetyl-4,4'-diaminodiphenylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

acetic anhydride (108-24-7) + 4,4'-diamino diphenyl methane (101-77-9) → N1-[4-(4-Aminobenzyl)phenyl]acetamide (24367-94-0)

Guidance literature:

With hydrogenchloride; In ethanol;

DOI:10.1021/tx950194+

Reference yield:

acetic anhydride (108-24-7) + 4,4'-diamino diphenyl methane (101-77-9) → N1-[4-(4-Aminobenzyl)phenyl]acetamide (24367-94-0) + N,N’-(methylenebis(4,1-phenylene))diacetamide (2719-05-3)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01216a052 DOI:10.1021/ja01851a005

Reference yield:

N-acetyl-S-[[4-(4-acetylaminobenzyl)phenyl]carbamoyl]-cysteine (1415322-04-1) → N1-[4-(4-Aminobenzyl)phenyl]acetamide (24367-94-0) + N-[4-({4-[({4-[4-acetamidobenzyl]phenyl}carbamoyl)-amino]phenyl}methyl)phenyl]acetamide

Guidance literature:

In aq. phosphate buffer; at 37 ℃; for 26h; pH=7.4;

DOI:10.1021/tx300347e

upstream raw materials:

acetic anhydride

4,4'-diamino diphenyl methane

N-Ac-L-Lys-OH

N-acetyl-S-[[4-(4-acetylaminobenzyl)phenyl]carbamoyl]-cysteine

Downstream raw materials:

(4-acetoacetylamino-phenyl)-(4-acetylamino-phenyl)-methane

4-(4-aminobenzyl)phenol

4-(4-bromobenzyl)aniline

N-acetyl-N'-tosyl-4,4'-diamino-diphenylmethane