1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride

Base Information

Chemical Name:1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride
CAS No.:93413-90-2
Molecular Formula:C16H25NO2.ClH
Molecular Weight:299.841
Hs Code.:2922504500
European Community (EC) Number:642-051-7
ChEMBL ID:CHEMBL1628258
DSSTox Substance ID:DTXSID80542837
Mol file:93413-90-2.mol

Synonyms:93413-90-2;1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride;Venlafaxine EP Impurity D;WY 45494 hydrochloride;1-[1-(4-methoxyphenyl)-2-(methylamino)ethyl]cyclohexan-1-ol;hydrochloride;1-[(1RS)-1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride;CHEMBL1628258;1-(1-(4-methoxyphenyl)-2-(methylamino)ethyl)cyclohexanol hydrochloride;HWPAFKGYJZARRM-UHFFFAOYSA-N;Venlafaxine Impurity D;DTXSID80542837;N-DESMETHYL VENLAFAXINE HCL;N-Desmethylvenlafaxine Hydrochloride;SB82548;A859796;EN300-18915504;Z3071317847;1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanolHydrochloride;N-Desmethylvenlafaxine Hydrochloride 1.0 mg/ml in Methanol (as free base);1-[1-(4-METHOXYPHENYL)-2-(METHYLAMINO)ETHYL]CYCLOHEXAN-1-OL HYDROCHLORIDE;1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexan-1-ol--hydrogen chloride (1/1);1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride(rac N-Desmethyl Venlafaxine Hydrochloride)

Suppliers and Price of 1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanolHydrochloride(racN-DesmethylVenlafaxineHydrochloride)
25mg
$ 285.00

TRC
1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanolHydrochloride(racN-DesmethylVenlafaxineHydrochloride)
10mg
$ 130.00

TRC
1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanolHydrochloride(racN-DesmethylVenlafaxineHydrochloride)
50mg
$ 510.00

Crysdot
1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanolHydrochloride 95+%
1g
$ 709.00

Chemenu
1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanolHydrochloride 95%
1g
$ 669.00

American Custom Chemicals Corporation
N-DESMETHYL VENLAFAXINE HYDROCHLORIDE 95.00%
5MG
$ 498.28

Alichem
1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanolHydrochloride
1g
$ 730.32

Total 18 raw suppliers

Chemical Property of 1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride

Chemical Property:

Melting Point:165-167℃
PSA：41.49000
LogP:3.88630
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:299.1652068
Heavy Atom Count:20
Complexity:256

Purity/Quality:

99%, ^*data from raw suppliers

1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanolHydrochloride(racN-DesmethylVenlafaxineHydrochloride) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNCC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl
Uses 1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride (Venlafaxine EP Impurity D; Venlafaxine USP Related Compound A) is a metabolite of Venlafaxine (V120000), which is a selective serotonin noradrenaline reuptake inhibitor, used as an antidepressant.

Technology Process of 1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride

There total 5 articles about 1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

: 149289-30-5
N-Desmethylvenlafaxine

: 93413-90-2
N-Desmethylvenlafaxine hydrochloride

Guidance literature:: With hydrogenchloride; In tert-butyl methyl ether; at 0 ℃; for 0.25h;

Reference yield:

: 93413-76-4,131801-69-9
1-[cyano(4-methoxyphenyl)methyl]cyclohexanol

: 93413-90-2
N-Desmethylvenlafaxine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: cobalt(II) chloride; sodium tetrahydroborate / methanol / 2 h / 20 - 35 °C

2: toluene / 4 h / Reflux

3: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 0 - 20 °C / Reflux

4: hydrogenchloride / tert-butyl methyl ether / 0.25 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; dimethylsulfide borane complex; cobalt(II) chloride; In tetrahydrofuran; methanol; tert-butyl methyl ether; toluene;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 93413-90-2
N-Desmethylvenlafaxine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - -65 °C

1.2: 2 h / -78 - -65 °C

2.1: cobalt(II) chloride; sodium tetrahydroborate / methanol / 2 h / 20 - 35 °C

3.1: toluene / 4 h / Reflux

4.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 0 - 20 °C / Reflux

5.1: hydrogenchloride / tert-butyl methyl ether / 0.25 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; dimethylsulfide borane complex; cobalt(II) chloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; tert-butyl methyl ether; toluene;