N-Desmethylvenlafaxine

Base Information

Chemical Name:N-Desmethylvenlafaxine
CAS No.:149289-30-5
Molecular Formula:C16H25 N O2
Molecular Weight:263.38
Hs Code.:
UNII:19V5EX4E8B
DSSTox Substance ID:DTXSID20881050
Nikkaji Number:J347.734G
Wikidata:Q27156915
Metabolomics Workbench ID:42516
ChEMBL ID:CHEMBL1119
Mol file:149289-30-5.mol

Synonyms:N-desmethyl venlafaxine;N-desmethylvenlafaxine

Suppliers and Price of N-Desmethylvenlafaxine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
racN-DesmethylVenlafaxine
50mg
$ 1165.00

Medical Isotopes, Inc.
D,LN-DesmethylVenlafaxine
25 mg
$ 1960.00

Medical Isotopes, Inc.
D,LN-DesmethylVenlafaxine
5 mg
$ 870.00

J&W Pharmlab
N-Desmethylvenlafaxine 98%
1g
$ 9998.00

J&W Pharmlab
N-Desmethylvenlafaxine 98%
500mg
$ 6720.00

J&W Pharmlab
N-Desmethylvenlafaxine 98%
100mg
$ 2240.00

J&W Pharmlab
N-Desmethylvenlafaxine 98%
10mg
$ 355.00

J&W Pharmlab
N-Desmethylvenlafaxine 98%
50mg
$ 1280.00

J&W Pharmlab
N-Desmethylvenlafaxine 98%
5mg
$ 198.00

American Custom Chemicals Corporation
DL N-DESMETHYLVENLAFAXINE 95.00%
50MG
$ 1686.30

Total 13 raw suppliers

Chemical Property of N-Desmethylvenlafaxine

Chemical Property:

Vapor Pressure:5.49E-07mmHg at 25°C
Melting Point:61-63°C
Refractive Index:1.543
Boiling Point:396.2°C at 760 mmHg
PKA:14.83±0.20(Predicted)
Flash Point:193.4°C
PSA：41.49000
Density:1.067g/cm³
LogP:3.08430
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:263.188529040
Heavy Atom Count:19
Complexity:256

Purity/Quality:

99%, ^*data from raw suppliers

racN-DesmethylVenlafaxine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNCC(C1=CC=C(C=C1)OC)C2(CCCCC2)O
Uses D,L N-Desmethylvenlafaxine is a metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant.

Technology Process of N-Desmethylvenlafaxine

There total 7 articles about N-Desmethylvenlafaxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.8%

: 272788-07-5
N-[2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide

: 149289-30-5
N-Desmethylvenlafaxine

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 5h; Reflux;

Reference yield:

: 593-51-1
methylamine hydrochloride

: 93413-76-4,131801-69-9
1-[cyano(4-methoxyphenyl)methyl]cyclohexanol

: 149289-30-5
N-Desmethylvenlafaxine

Guidance literature:: With hydrogen; Pd-alumina; In methanol; at 20 ℃; for 24h; under 760.051 - 1520.1 Torr;

Reference yield:

: 104-47-2
p-methoxybenzylnitrile

: 149289-30-5
N-Desmethylvenlafaxine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BuLi / 1.) THF, hexane, -70 deg C, 30 min, 2.) -65 deg C, 2 h

2: H₂ / 5percent Rh/Al₂O₃ / ethanol; aq. NH₃

3: 1.) NaHCO₃, 2.) LiAlH₄ / 1.) CH₂Cl₂, RT, 20 h, 2.) THF, reflux, 1.5 h

With lithium aluminium tetrahydride; n-butyllithium; hydrogen; sodium hydrogencarbonate; Rh/Al₂O₃; In ammonium hydroxide; ethanol;
DOI:10.1021/jm00172a035