1-METHYL-4-ETHOXYCARBONYL PYRAZOLE-5-SULFONYL CHLORIDE

Base Information

• Chemical Name: 1-METHYL-4-ETHOXYCARBONYL PYRAZOLE-5-SULFONYL CHLORIDE
• CAS No.: 93621-38-6
• Molecular Formula: C₇H₉ClN₂O₄S
• Molecular Weight: 252.678
• Hs Code.: 2933199090
• Mol file: 93621-38-6.mol

Synonyms:

Chemical Property of 1-METHYL-4-ETHOXYCARBONYL PYRAZOLE-5-SULFONYL CHLORIDE

Chemical Property:

• PSA: 86.64000
• LogP: 1.60510

Purity/Quality:

99%min ^*data from raw suppliers

1-METHYL-4-ETHOXYCARBONYL PYRAZOLE-5-SULFONYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYL-4-ETHOXYCARBONYL PYRAZOLE-5-SULFONYL CHLORIDE

There total 1 articles about 1-METHYL-4-ETHOXYCARBONYL PYRAZOLE-5-SULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (21230-43-3) → ethyl 3-chlorosulfonyl-1-methylpyrazole-4-carboxylate (93621-38-6)

Guidance literature:

With hydrogenchloride; sulfur dioxide; copper dichloride; sodium nitrite; Yield given. Multistep reaction; 1) Acetic acid, formic acid, -8 to -6 deg C, 5 min, 2) room temperature, 15 deg C_.;

DOI:10.1002/jhet.5570210418

Reference yield: 92.0%

ethyl 3-chlorosulfonyl-1-methylpyrazole-4-carboxylate (93621-38-6) + N-methylaniline (100-61-8) → ethyl 1-methyl-3-(N-phenyl-N-methyl)sulfamoylpyrazole-4-carboxylate (155144-47-1)

Guidance literature:

In tetrahydrofuran; for 1h; Heating;

DOI:10.1002/jhet.5570310117

Reference yield: 85.0%

ethyl 3-chlorosulfonyl-1-methylpyrazole-4-carboxylate (93621-38-6) → 1-Methyl-3-sulfamoyl-1H-pyrazole-4-carboxylic acid ethyl ester (95302-42-4)

Guidance literature:

With ammonia; at 0 ℃; for 4h;

DOI:10.1002/ardp.19963290503

upstream raw materials:

3-amino-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

Downstream raw materials:

ethyl 1-methyl-3-(N-phenyl-N-methyl)sulfamoylpyrazole-4-carboxylate

ethyl 1-methyl-3-(N-3'-pyridyl)sulfamoylpyrazole-4-carboxylate

ethyl 1-methyl-3-(N-2'-pyridyl)sulfamoylpyrazole-4-carboxylate

1-Methyl-3-sulfamoyl-1H-pyrazole-4-carboxylic acid ethyl ester

Refernces

• 1、 Diaz,Vega. "Synthesis of 1H- and 2H-pyrazolo[3,4-c][2,1]benzothiazepines". . p. 93 - 96. Retrieved 2007/10/02.