Ethyl 1-methyl-3-((2-pyridinylamino)sulfonyl)-1H-pyrazole-4-carboxylate

Base Information

Chemical Name:Ethyl 1-methyl-3-((2-pyridinylamino)sulfonyl)-1H-pyrazole-4-carboxylate
CAS No.:178880-00-7
Molecular Formula:C₁₂H₁₄N₄O₄S
Molecular Weight:310.334
Hs Code.:
DSSTox Substance ID:DTXSID60939125
Nikkaji Number:J762.283J
Wikidata:Q82915571
Mol file:178880-00-7.mol

Synonyms:178880-00-7;ethyl 1-methyl-3-(pyridin-2-ylsulfamoyl)pyrazole-4-carboxylate;Ethyl 1-methyl-3-((2-pyridinylamino)sulfonyl)-1H-pyrazole-4-carboxylate;Ethyl 1-methyl-3-(N-2'-pyridyl)-sulfamoylpyrazole-4-carboxylate;1H-Pyrazole-4-carboxylic acid, 1-methyl-3-((2-pyridinylamino)sulfonyl)-, ethyl ester;DTXSID60939125;XMFYKSLMYIDOFR-UHFFFAOYSA-N;LS-128371;Ethyl 1-methyl-3-[(pyridin-2-yl)sulfamoyl]-1H-pyrazole-4-carboxylate;1-Methyl-3-[(2-pyridinyl)sulfamoyl]-1H-pyrazole-4-carboxylic acid ethyl ester

Suppliers and Price of Ethyl 1-methyl-3-((2-pyridinylamino)sulfonyl)-1H-pyrazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Ethyl 1-methyl-3-((2-pyridinylamino)sulfonyl)-1H-pyrazole-4-carboxylate

Chemical Property:

Vapor Pressure:5.48E-11mmHg at 25°C
Boiling Point:521.8°Cat760mmHg
Flash Point:269.4°C
PSA：111.56000
Density:1.43g/cm³
LogP:1.94640
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:310.07357611
Heavy Atom Count:21
Complexity:464

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN(N=C1S(=O)(=O)NC2=CC=CC=N2)C

Technology Process of Ethyl 1-methyl-3-((2-pyridinylamino)sulfonyl)-1H-pyrazole-4-carboxylate

There total 1 articles about Ethyl 1-methyl-3-((2-pyridinylamino)sulfonyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 504-29-0
2-aminopyridine

: 93621-38-6
ethyl 3-chlorosulfonyl-1-methylpyrazole-4-carboxylate

: 178880-00-7
ethyl 1-methyl-3-(N-2'-pyridyl)sulfamoylpyrazole-4-carboxylate

Guidance literature:: In tetrahydrofuran; for 2h; Heating;
DOI:10.1002/ardp.19963290503

Reference yield: 78.0%

: 178880-00-7
ethyl 1-methyl-3-(N-2'-pyridyl)sulfamoylpyrazole-4-carboxylate

: 74-88-4
methyl iodide

: 178880-02-9
ethyl 1-methyl-3-(N-methyl-N-2'-pyridyl)sulfamoylpyrazole-4-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1002/ardp.19963290503

Reference yield:

: 178880-00-7
ethyl 1-methyl-3-(N-2'-pyridyl)sulfamoylpyrazole-4-carboxylate

: 178880-03-0
1-methyl-3-(N-methyl-N-2'-pyridyl)sulfamoylpyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / NaH / dimethylformamide / 72 h / Ambient temperature

2: 78 percent / 1 N aq. NaOH / 2 h / Heating

With sodium hydroxide; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1002/ardp.19963290503