N-(3-imidazol-1-ylpropyl)-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(3-imidazol-1-ylpropyl)-4-(trifluoromethyl)benzamide
CAS No.:93669-31-9
Molecular Formula:C14H14F3N3O
Molecular Weight:297.28
Hs Code.:
DSSTox Substance ID:DTXSID301190423
ChEMBL ID:CHEMBL146743

Synonyms:93669-31-9;N-[3-(1H-imidazol-1-yl)propyl]-4-(trifluoromethyl)benzamide;N-[3-(1H-imidazol-1-yl)propyl]-4-(trifluoromethyl)benzenecarboxamide;N-(3-(1H-imidazol-1-yl)propyl)-4-(trifluoromethyl)benzamide;N-(3-imidazol-1-ylpropyl)-4-(trifluoromethyl)benzamide;MLS001195422;CHEMBL146743;DTXSID301190423;HMS2878C08;AKOS001102345;MS-0246;SMR000550663;CS-0367712;SR-01000309749;SR-01000309749-1;Z31795502

Suppliers and Price of N-(3-imidazol-1-ylpropyl)-4-(trifluoromethyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of N-(3-imidazol-1-ylpropyl)-4-(trifluoromethyl)benzamide

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:297.10889656
Heavy Atom Count:21
Complexity:341

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)NCCCN2C=CN=C2)C(F)(F)F

Technology Process of N-(3-imidazol-1-ylpropyl)-4-(trifluoromethyl)benzamide

There total 2 articles about N-(3-imidazol-1-ylpropyl)-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 5036-48-6
3-(1H-imidazol-1-yl)propan-1-amine

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 93669-31-9
N-(3-(1H-imidazol-1-yl)propyl)-4-(trifluoromethyl)benzamide

Guidance literature:: With TEA; In dichloromethane; at 20 ℃;
DOI:10.1080/14756366.2017.1327522

Reference yield:

: 23996-53-4
3-imidazol-1-yl-propionitrile

: 93669-31-9
N-(3-(1H-imidazol-1-yl)propyl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, NH₄OH / Raney-Ni / methanol

2: 52 percent / 1 N aq. NaOH / CH₂Cl₂

With ammonium hydroxide; sodium hydroxide; hydrogen; nickel; In methanol; dichloromethane;
DOI:10.1021/jm00154a017