5036-48-6

Basic information

• Product Name: N-(3-Aminopropyl)-imidazole
• Synonyms: N-(3-AMINOPROPYL)IMIDAZOLE;LUPRAGEN(R) API;1-(3-AMINOPROPYL)IMIDAZOLE;3-(1-IMIDAZOLYL)-1-PROPYLAMINE;3-(IMIDAZOL-1-YL)PROPYLAMINE;1H-Imidazole-1-propanamine;3-(1H-Imidazol-1-yl)-1-propanamine;1H-imidazole-1-propylamine
• CAS NO: 5036-48-6
• Molecular Formula: C₆H₁₁N₃
• Molecular Weight: 125.17
• EINECS: 225-730-9
• Product Categories: Heterocycles series;Building Blocks;Heterocyclic Building Blocks;Imidazoles
• Mol File: 5036-48-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: -68 °C
• Boiling Point: 296 °C
• Flash Point: >230 °F
• Appearance: Clear colorless/Liquid
• Density: 1.049 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00245mmHg at 25°C
• Refractive Index: n20/D 1.519(lit.)
• Storage Temp.: Store below +30°C.
• PKA: 9.08±0.10(Predicted)
• Explosive Limit: 1.0-6.4%(V)
• Water Solubility: miscible
• CAS DataBase Reference: N-(3-Aminopropyl)-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Aminopropyl)-imidazole(5036-48-6)
• EPA Substance Registry System: N-(3-Aminopropyl)-imidazole(5036-48-6)

Safety Data

• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3267 8/PG 2
• WGK Germany: 1
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 5036-48-6(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

Different sources of media describe the Uses of 5036-48-6 differently. You can refer to the following data:
1. 1-(3-Aminopropyl)imidazole is used in the synthesis of pH-sensitive polyaspartamide derivatives. It is also used in the preparation of pH-sensitive amphiphilic polymers with different degrees of octaceylamine (C18) substitution by graft reaction.
2. 1-(3-Aminopropyl)imidazole was used in the synthesis of pH-sensitive polyaspartamide derivatives. It was also used in the preparation of pH-sensitive amphiphilic polymers with different degrees of octaceylamine (C18) substitution by graft reaction.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C6H11N3/c7-2-1-4-9-5-3-8-6-9/h3,5-6H,1-2,4,7H2/p+1

Upstream product

• 17583-35-6 2-(3-(1H-imidazol-1-yl)propyl)isoindoline-1,3-dione 
• 23996-53-4 3-imidazol-1-yl-propionitrile 
• 288-32-4 1H-imidazole 
• 1336-21-6 ammonium hydroxide 
• 107-13-1 acrylonitrile 

Downstream Products

• 95059-40-8 N-[3-(1H-imidazol-1-yl)propyl]-2-furanecarboxamide 
• 75526-89-5 meso-tri(α,α,α-o-pivalamidophenyl)-β-o-3-(N-imidazolyl)propylureidophenylporphyrin 
• 75535-73-8 meso-monotriphenylporphyrin 
• 85294-25-3 5,10,15-((1,3,5-benzenetriyltriacetyl)tris(α,α,α-o-aminophenyl))-20-(β-o-3-(N-imidazolyl)propylureidophenyl)porphyrin 
• 93668-26-9 N-[3-(1H-imidazol-1-yl)propyl]phthalamic acid 
• 93668-39-4 4-Chloro-2-(3-imidazol-1-yl-propyl)-isoindole-1,3-dione 
• 93668-81-6 (E)-3-(4-Chloro-phenyl)-N-(3-imidazol-1-yl-propyl)-acrylamide 
• 90259-60-2 2-Amino-N-[3-(1H-imidazole-1-yl)propyl]benzamide 
• 95458-28-9 3-Chloro-6-methyl-benzo[b]thiophene-2-carboxylic acid (3-imidazol-1-yl-propyl)-amide 
• 93669-29-5 3-Bromo-N-(3-imidazol-1-yl-propyl)-benzamide 
• 100468-15-3 2-Phenyl-cyclopropanecarboxylic acid (3-imidazol-1-yl-propyl)-amide 
• 93669-36-4 N-(3-Imidazol-1-yl-propyl)-3-trifluoromethyl-benzamide 
• 90260-19-8 2-methylamino-N-(3-imidazol-1-ylpropyl)benzamide 
• 93668-83-8 2-Ethylamino-N-(3-imidazol-1-yl-propyl)-benzamide 

Relevant articles and documents

Method for synthesizing 1-(3-aminopropyl)imidazole from imidazole

The invention discloses a method for synthesizing 1-(3-aminopropyl)imidazole from imidazole. The method comprises the following steps: a, adding 28-32 parts by weight of the imidazole, 55-65 parts byweight of acrylonitrile, and 0.9-1.1 parts by weight of ethyl acetate into a reaction kettle, rapidly raising the temperature to 42-44 DEG C under sealed conditions, and performing stirring continuously for 22-28min; and introducing a nitrogen gas for cooling until the temperature is -5 DEG C, adding dilute sulfuric acid to adjust the pH value to 2.2-2.4, and performing stirring for 10-20min for precipitating a crystal; b, washing the crystal with saturated salt water, performing vacuum drying, and performing cooling to normal temperature to obtain N-(2-cyanoethyl)imidazole and other steps. The preparation method provided by the invention is scientific and simple, strictly controls the formula ratio, and controls the reaction conditions, the raw materials are easy to obtain, the usage amount of the raw materials is small, the cost is low, and the prepared 1-(3-aminopropyl)imidazole has high purity, a high yield and stable performance, and is suitable for industrialized production.

Gyrrolone and pyrromonazole compound and its use as medicine

The present invention belongs to the technical field of medicine. Provided in the present invention is pyrrolidone compounds, including optical isomers, racemates, cis and trans isomers and any combination thereof or pharmaceutically acceptable salts thereof, having a structure as shown in formula (I). The compounds of the present invention can be used as a small molecule inhibitor for p53-MDM2/X protein interactions. The compounds of the present invention can be used to prepare antineoplastic or anti-inflammatory drugs.

Encapsulation of a catalytic imidazolium salt into avidin: Towards the development of a biohybrid catalyst active in ionic liquids

Herein, we report the development of biohybrid catalysts that are capable of catalyzing the aldol reaction. The use of biotinylated imidazolium salts in combination with racemic or enantiomerically pure catalytic anions allowed us to study the adaptive and cooperative positioning of the anionic catalyst inside the protein. Supramolecular encapsulation of the biotinylated catalyst into avidin resulted in good selectivity for the aldol reaction performed in ionic liquid/water mixtures. Biohybrid catalysts capable of catalyzing the aldol reaction are prepared from avidin and biotinylated imidazolium salts with either racemic or enantiomerically pure catalytic anions. Supramolecular encapsulation (see figure) of the biotinylated catalyst in avidin resulted in good selectivities for the aldol reaction when performed in ionic liquid/water mixtures and the adaptive and cooperative positioning of the anionic catalyst inside the avidin protein is discussed. Copyright