2,7-Diacetamidofluorene

Base Information

• Chemical Name: 2,7-Diacetamidofluorene
• CAS No.: 304-28-9
• Molecular Formula: C17H16 N2 O2
• Molecular Weight: 280.326
• European Community (EC) Number: 206-153-1
• NSC Number: 12282
• UNII: O61IVF6HX7
• DSSTox Substance ID: DTXSID9021479
• Nikkaji Number: J1.520B
• Wikidata: Q27888927
• ChEMBL ID: CHEMBL84749
• Mol file: 304-28-9.mol

Synonyms:2,7 diacetylaminofluorene;2,7-diacetylaminofluorene;2,7-fluorenylbisacetamide;2,7-fluorenyldiacetamide;N,N'-2,7-fluorenylenebisacetamide;N,N'-fluorene-2,7-ylenebisacetamide

Chemical Property of 2,7-Diacetamidofluorene

Chemical Property:

• Vapor Pressure: 4.86E-15mmHg at 25°C
• Melting Point: 281 °C
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 614.6°Cat760mmHg
• PKA: 14.52±0.20(Predicted)
• Flash Point: 246.9°C
• PSA: 58.20000
• Density: 1.306g/cm³
• LogP: 3.32060
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 280.121177757
• Heavy Atom Count: 21
• Complexity: 385

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,7-Di(acetamido)fluorene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC2=C(C=C1)C3=C(C2)C=C(C=C3)NC(=O)C

Technology Process of 2,7-Diacetamidofluorene

There total 20 articles about 2,7-Diacetamidofluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,7-fluorenediamine (525-64-4) + acetic anhydride (108-24-7) → N,N'-(9H-fluorene-2,7-diyl)diacetamide (304-28-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.inorgchem.7b01958

Reference yield: 75.0%

2,7-fluorenediamine (525-64-4) + acetic anhydride (108-24-7) + acetic acid (64-19-7,77671-22-8) → N,N'-(9H-fluorene-2,7-diyl)diacetamide (304-28-9)

Guidance literature:

for 0.5h; Reflux; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4dt03572k

Reference yield: 56.0%

2,7-bis(acetylamino)-3,6-di-t-butylfluorene (106112-45-2) → N,N'-(9H-fluorene-2,7-diyl)diacetamide (304-28-9)

Guidance literature:

With aluminium trichloride; In benzene; at 50 ℃; for 0.5h;

DOI:10.1246/bcsj.59.97

upstream raw materials:

2,7-diacetylfluorene dioxime

2,7-fluorenediamine

acetic anhydride

acetic acid

Downstream raw materials:

2,7-fluorenediamine

3,6-dichloro-9H-fluoren-9-one

3,6-dinitrofluoren-9-one

3,6-diamino-9-fluorenone

Refernces

• 1、 Bindewald, Elvira,Lorenz, Roxana,Hübner, Olaf,Brox, Dominik,Herten, Dirk-Peter,Kaifer, Elisabeth,Himmel, Hans-J?rg. "Tetraguanidino-functionalized phenazine and fluorene dyes: Synthesis, optical properties and metal coordination". . p. 3467 - 3485. Retrieved 2015/03/05.