1-(4-(4-broMophenoxy)butyl)-4-Methylpiperazine

Base Information

• Chemical Name: 1-(4-(4-broMophenoxy)butyl)-4-Methylpiperazine
• CAS No.: 93699-37-7
• Molecular Formula: C14H21BrN2O
• Molecular Weight: 313.238
• Mol file: 93699-37-7.mol

Synonyms:1-(4-(4-bromophenoxy)butyl)-4-methylpiperazine;

Chemical Property of 1-(4-(4-broMophenoxy)butyl)-4-Methylpiperazine

Chemical Property:

• PSA: 15.71000
• LogP: 2.34120

Purity/Quality:

99% ^*data from raw suppliers

1-(3-(4-Bromophenoxy)propyl)-4-methylpiperazine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-(4-broMophenoxy)butyl)-4-Methylpiperazine

There total 1 articles about 1-(4-(4-broMophenoxy)butyl)-4-Methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-methyl-piperazine (109-01-3) + 1-bromo-4-(3'-bromopropoxy)benzene (7497-87-2) → 1-bromo-4-[3-(4-methylpiperazin-1-yl)propoxy]benzene (93699-37-7)

Guidance literature:

With caesium carbonate; In acetonitrile; at 75 ℃; for 5h;

Reference yield: 75.0%

1-bromo-4-[3-(4-methylpiperazin-1-yl)propoxy]benzene (93699-37-7) + methyl 6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-1H-indole-3-carboxylate (1467060-68-9) → methyl 6-chloro-5-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-1H-indole-3-carboxylate (1467060-88-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In ethanol; water; toluene; at 110 ℃; for 2.5h;

Reference yield: 55.0%

1-bromo-4-[3-(4-methylpiperazin-1-yl)propoxy]benzene (93699-37-7) → 4-[3-(4-methylpiperazin-1-yl)-propoxy]phenylboronic acid (1003028-43-0)

Guidance literature:

1-bromo-4-[3-(4-methylpiperazin-1-yl)propoxy]benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

With Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With ammonium chloride; In tetrahydrofuran; hexane; Further stages.;

DOI:10.1016/j.tet.2007.10.045

upstream raw materials:

1-methyl-piperazine

1-bromo-4-(3'-bromopropoxy)benzene

Downstream raw materials:

4-[3-(4-methylpiperazin-1-yl)-propoxy]phenylboronic acid

1-(4-chlorophenyl)-1-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-phenyl}-propan-1-ol

methyl 6-chloro-5-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-1H-indole-3-carboxylate

6-chloro-5-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-1H-indole-3-carboxylic acid

Refernces

• 1、 Le Sann, Christine,Huddleston, Jonathan,Mann, John. "Synthesis and preliminary evaluation of novel analogues of quindolines as potential stabilisers of telomeric G-quadruplex DNA". . p. 12903 - 12911. Retrieved 2008/03/27.