7497-87-2

Usage

Uses

Used in Organic Synthesis:
1-(3-BROMOPROPOXY)-4-BROMOBENZENE is used as a building block in organic synthesis for creating a variety of organic compounds with tailored properties and functions. Its presence of bromine atoms and propoxy group allows for further chemical reactions and modifications, making it a valuable component in the development of new chemical entities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-(3-BROMOPROPOXY)-4-BROMOBENZENE is utilized as an intermediate in the production of various pharmaceuticals. Its unique structure and functional groups contribute to the synthesis of drugs with specific therapeutic effects, enhancing the range of available treatments for different medical conditions.
Used in Agrochemical Industry:
1-(3-BROMOPROPOXY)-4-BROMOBENZENE also finds application in the agrochemical industry, where it is employed as an intermediate in the synthesis of agrochemicals. Its role in creating compounds with pesticidal or herbicidal properties helps in the development of effective solutions for crop protection and management.
Safety Considerations:
Due to the presence of bromine atoms, 1-(3-BROMOPROPOXY)-4-BROMOBENZENE is considered hazardous, and appropriate safety measures should be taken during its handling and use. This includes proper storage, handling procedures, and protective equipment to minimize potential risks to human health and the environment.

InChI:InChI=1/C9H10Br2O/c10-6-1-7-12-9-4-2-8(11)3-5-9/h2-5H,1,6-7H2

Upstream product

• 106-41-2 4-bromo-phenol 
• 109-64-8 1,3-dibromo-propane 
• 627-18-9 1-bromo-3-propanol 
• 67900-64-5 3-(4-Bromophenoxy)-1-propanol 
• 124-63-0 methanesulfonyl chloride 
• 121-44-8 triethylamine 
• 55580-07-9 4-(4-bromophenoxy)butanoic acid 
• 157245-87-9 4-(4-bromophenoxy)butyric acid ethyl ester 
• 25244-30-8 4-(allyloxy)bromobenzene 

Downstream Products

• 7494-06-6 3-(4-bromo-phenoxy)-propylsulfanyl cyanate 
• 588-63-6 3-phenoxypropyl bromide 
• 108-95-2 phenol 
• 76579-64-1 3-(4-bromophenoxy)-N,N-dimethyl-propan-1-amine 
• 1026543-63-4 N-[3-(4-bromo-phenoxy)-propoxy]-acetamide 
• 93699-37-7 1-bromo-4-[3-(4-methylpiperazin-1-yl)propoxy]benzene 
• 1467060-87-2 methyl 6-chloro-5-{4-[3-(piperazin-1-yl)propoxy]phenyl}-1H-indole-3-carboxylate 
• 1467058-41-8 6-chloro-5-{4-[3-(piperazin-1-yl)propoxy]phenyl}-1H-indole-3-carboxylic acid 
• 1467060-90-7 methyl 6-chloro-5-{4-[3-(3-oxomorpholin-4-yl)propoxy]phenyl}-1H-indole-3-carboxylate 
• 1467058-44-1 6-chloro-5-{4-[3-(3-oxomorpholin-4-yl)propoxy]phenyl}-1H-indole-3-carboxylic acid 
• 1467060-86-1 tert-butyl 4-(3-(4-bromophenoxy)propyl)piperazine-1-carboxylate 
• 1467060-89-4 4-(3-(4-bromophenoxy)propyl)morpholin-3-one 
• 1467060-88-3 methyl 6-chloro-5-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-1H-indole-3-carboxylate 
• 1467058-43-0 6-chloro-5-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-1H-indole-3-carboxylic acid 

Relevant academic research and scientific papers

Preparation method 3 - phenoxybromopropane or analogue thereof

The invention discloses a preparation method of 3 -phenoxybromopropane or an analogue thereof, wherein 3 - phenoxybromopropane and an allyl compound thereof are obtained through substitution reaction and addition reaction so as to avoid the inconvenience of using gaseous hydrogen bromide, 2nd-step addition reaction is realized by using the brominated salt and the acid in situ, and the process is simple in operation. The condition is easy to control, the atom economy is good, the aspect of environmental impact is low pollution, zero emission accords with the current green chemical synthesis direction, and the cost is economic.

Novel compound, polymer prepared therefrom, and organic light emitting device comprising the polymer

The present invention relates to a novel compound, a copolymer prepared therefrom, and an organic light emitting device comprising the copolymer.COPYRIGHT KIPO 2020

POLYCYCLIC COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES

The present disclosure relates to bifunctional compounds, ULM— L—PTM, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A- RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure.

Twist-bend nematic liquid crystals based on thioether linkage

We developed twist-bend nematogens based on cyanobiphenyl dimers with thioether or sulfur linkage, as opposed to the commonly used methylene and ether linkages. Based on the smaller bond angle of thioether C-S-C than methylene C-CH2-C and ether

Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis

Clinical treatment of cryptococcal meningitis (CM) remains a significant challenge because of the lack of effective and safe drug therapies. Developing novel CM therapeutic agents with novel chemical scaffolds and new modes of action is of great importanc

Compound with spiro structure, preparation method and application thereof

The invention discloses a compound with a spiro structure, a preparation method and application thereof. The compound with a spiro structure shown as formula I, formula II or formula III or pharmaceutically acceptable salts thereof have excellent hDHFR inhibitory activity, antitumor activity and antibacterial activity.

Design, synthesis, docking studies and biological evaluation of novel dihydro-1,3,5-triazines as human DHFR inhibitors

A novel series of dihydro-1,3,5-triazine derivatives bearing a heteroatom spiro-ring were designed and synthesized on the basis of molecular flexible docking work, and their biological activities were evaluated. Compounds A2, A5, B1 and B3 showed potent human dihydrofolate reductase (hDHFR) inhibitory activity with IC50values of 7.46 nM, 3.72 nM, 6.46 nM, 4.08 nM, versus reference drug methotrexate (MTX). From the molecular docking result we concluded that the conformation space generated by deformation of the flexible residue Phe31 is favorable for the binding of the spiro-ring, and inserting heteroatom into spiro ring might increase the binding affinity. There were 24 compounds with broadspectrum antiproliferative activity against several tumor cell lines (HCT116, A549, HL-60, HepG2 and MDA-MB-231) with IC50values ranging from 0.79 to 0.001 μM. The antitumor activity in?vivo of compound A2 was determined in a human alveolar basal epithelial cell line A549 xenograft model. This study offered novel anticancer agents with high inhibitory activity that target hDHFR and have a binding mode of the novel molecular scaffold with hDHFR. This provides potent support for further development of novel hDHFR inhibitors.

Catalytic Access to Alkyl Bromides, Chlorides and Iodides via Visible Light-Promoted Decarboxylative Halogenation

Herein is reported the catalytic, visible light-promoted, decarboxylative halogenation (bromination, chlorination, and iodination) of aliphatic carboxylic acids. This operationally-simple reaction tolerates a range of functional groups, proceeds at room temperature, and is redox neutral. By employing an iridium photocatalyst in concert with a halogen atom source, the use of stoichiometric metals such as silver, mercury, thallium, and lead can be circumvented. This reaction grants access to valuable synthetic building blocks from the large pool of cheap, readily available carboxylic acids.

Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides

The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives - previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N-(4-phenoxyphenyl)acetamide side chain at N3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action.

Design and synthesis of guanylthiourea derivatives as potential inhibitors of Plasmodium falciparum dihydrofolate reductase enzyme

A new class of compounds based on S-benzylated guanylthiourea has been designed as potential PfDHFR inhibitors using computer aided methods (molecular electrostatic potential, molecular docking). Several compounds in this class have been synthesized start