Farnesylamine

Base Information

• Chemical Name: Farnesylamine
• CAS No.: 6784-46-9
• Molecular Formula: C15H27N
• Molecular Weight: 221.386
• Hs Code.: 2921199090
• Nikkaji Number: J37.664G,J728.129C
• ChEMBL ID: CHEMBL4215890
• Mol file: 6784-46-9.mol

Synonyms:farnesylamine

Chemical Property of Farnesylamine

Chemical Property:

• Vapor Pressure: 0.00036mmHg at 25°C
• Boiling Point: 318.5°Cat760mmHg
• Flash Point: 137.2°C
• PSA: 26.02000
• Density: 0.851g/cm³
• LogP: 5.06460
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 7
• Exact Mass: 221.214349865
• Heavy Atom Count: 16
• Complexity: 265

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=CCCC(=CCCC(=CCN)C)C)C
• Isomeric SMILES: CC(=CCC/C(=C/CC/C(=C/CN)/C)/C)C

Technology Process of Farnesylamine

There total 11 articles about Farnesylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

farnesyl bromide (24163-93-7,24163-94-8,56881-57-3,6874-67-5,28290-41-7) → farnesylamine (6784-46-9,129121-59-1)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; for 16h; Inert atmosphere;

DOI:10.1021/jacs.5b04501

Reference yield: 100.0%

N-farnesylphtalimide (123022-37-7) → farnesylamine (6784-46-9,129121-59-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 10h; Heating;

DOI:10.1021/jo981617q

Reference yield: 97.0%

farnesol (4602-84-0) → farnesyl amine (6784-46-9)

Guidance literature:

farnesol; With lithium hexamethyldisilazane; at 0 - 20 ℃; Inert atmosphere;

With methanol; Inert atmosphere;

DOI:10.1021/jo400960e

upstream raw materials:

farnesol

N-farnesyltrifluoroacetamide

N-farnesylphtalimide

4-Methyl-N-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-benzenesulfonamide

Downstream raw materials:

N-homogeranyl-N-methyl-N'-farnesylformamidine

Refernces

• 1、 Kim, Choon,Hesek, Dusan,Lee, Mijoon,Mobashery, Shahriar. "Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives". . p. 642 - 645. Retrieved 2018/02/09.
• 2、 Koopmans, Timo,Wood, Thomas M.,'T Hart, Peter,Kleijn, Laurens H. J.,Hendrickx, Antoni P. A.,Willems, Rob J. L.,Breukink, Eefjan,Martin, Nathaniel I.. "Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound". supporting information. p. 9382 - 9389. Retrieved 2015/08/06.